Corelease of dopamine and serotonin from striatal dopamine terminals

Fuming Zhou, Yong Liang, Ramiro Salas, Lifen Zhang, Mariella De Biasi, John A. Dani

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The striatum receives rich dopaminergic and more moderate serotonergic innervation. After vesicular release, dopamine and serotonin (5-hydroxytryptamine, 5-HT) signaling is controlled by transporter-mediated reuptake. Dopamine is taken up by dopamine transporters (DATs), which are expressed at the highest density in the striatum. Although DATs also display a low affinity for 5-HT, that neurotransmitter is normally efficiently taken up by the 5-HT transporters. We found that when extracellular 5-HT is elevated by exogenous application or by using antidepressants (e.g., fluoxetine) to inhibit the 5-HT transporters, the extremely dense striatal DATs uptake 5-HT into dopamine terminals. Immunohistochemical results and measurements using fast cyclic voltammetry showed that elevated 5-HT is taken up by DATs into striatal dopamine terminals that subsequently release 5-HT and dopamine together. These results suggest that antidepressants that block serotonin transporters or other factors that elevate extracellular 5-HT alter the temporal and spatial relationship between dopamine and 5-HT signaling in the striatum.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalNeuron
Volume46
Issue number1
DOIs
StatePublished - Apr 7 2005

Fingerprint

Corpus Striatum
Dopamine
Serotonin
Dopamine Plasma Membrane Transport Proteins
Antidepressive Agents
Serotonin Plasma Membrane Transport Proteins
Fluoxetine
Neurotransmitter Agents

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Zhou, F., Liang, Y., Salas, R., Zhang, L., De Biasi, M., & Dani, J. A. (2005). Corelease of dopamine and serotonin from striatal dopamine terminals. Neuron, 46(1), 65-74. https://doi.org/10.1016/j.neuron.2005.02.010

Corelease of dopamine and serotonin from striatal dopamine terminals. / Zhou, Fuming; Liang, Yong; Salas, Ramiro; Zhang, Lifen; De Biasi, Mariella; Dani, John A.

In: Neuron, Vol. 46, No. 1, 07.04.2005, p. 65-74.

Research output: Contribution to journalArticle

Zhou, F, Liang, Y, Salas, R, Zhang, L, De Biasi, M & Dani, JA 2005, 'Corelease of dopamine and serotonin from striatal dopamine terminals', Neuron, vol. 46, no. 1, pp. 65-74. https://doi.org/10.1016/j.neuron.2005.02.010
Zhou, Fuming ; Liang, Yong ; Salas, Ramiro ; Zhang, Lifen ; De Biasi, Mariella ; Dani, John A. / Corelease of dopamine and serotonin from striatal dopamine terminals. In: Neuron. 2005 ; Vol. 46, No. 1. pp. 65-74.
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