Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension response to captopril

Jorge E. Jalxl, Joseph S. Janicki, Ruth Pick, Karl Weber

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Abstract

Progressive myocardial fibrosis, including the ac­cumulation of collagen within the adventitia of in­tramyocardial coronary arteries, is seen in the hy­pertrophied rat myocardium secondary to renovascular hypertension (RHT) and has been held responsible for alterations in myocardial diastolic stiffness. This study was undertaken to test the hypothesis that this presumptive angiotensin - aldosterone mediated fibrosis and its functional consequences could be favorably altered by an an­tihypertensive oral dose (50 mg/kg/day) of the an­giotensin converting enzyme (ACE) inhibitor cap- topril. Three groups were studied: Control; untreated RHT for 8 weeks; treated RHT, with captopril started 48 h before banding and continued for 8 weeks. Interstitial collagen volume fraction and perivascular collagen area (morphometry), the fibril­lar nature of collagen (picrosirius polarization), and the end diastolic stress-strain re­lation of the intact left ventricle were examined in each group. In comparison to untreated animals with RHT, we found that captopril, begun prior to banding, attenuated interstitial and perivascular fibrosis and prevented hypertrophy and the rise in diastolic stiffness 8 weeks later. Thus, an adverse accumulation of collagen in the interstitium and around intramyocardial coronary arteries, and its functional consequences in the rat with RHT, can be prevented by captopril. Other ACE inhibitors may have similar salutary effects, but remain to be evaluated. The pathogenetic origin of myocardial fibrosis in RHT requires further investigation, but appears to be related to the angiotensin-aldosterone system.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalAmerican journal of hypertension
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1991

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Renovascular Hypertension
Captopril
Fibrosis
Collagen
Angiotensins
Aldosterone
Angiotensin-Converting Enzyme Inhibitors
Coronary Vessels
Fibrillar Collagens
Adventitia
Hypertrophy
Antihypertensive Agents
Heart Ventricles
Vascular Remodeling
Myocardium

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension response to captopril. / Jalxl, Jorge E.; Janicki, Joseph S.; Pick, Ruth; Weber, Karl.

In: American journal of hypertension, Vol. 4, No. 1, 01.01.1991, p. 51-55.

Research output: Contribution to journalArticle

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