Corpus callosotomy for medically intractable seizures

Jeffrey Sorenson, James Wheless, James E. Baumgartner, Azreena B. Thomas, Bonnie L. Brookshire, Guy L. Clifton, James Willmore

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To identify factors influencing outcome and morbidity in patients selected for corpus callosotomy, we retrospectively reviewed 23 patients with intractable generalized seizures who underwent corpus callosotomy between 1991 and 1994. Three patients had a complete corpus callosotomy, while 20 had an anterior callosotomy. Three of those patients subsequently had completion of the anterior callosotomy. Overall, 41% of patients were nearly or completely free of the seizure types targeted for surgical treatment, while another 45 % had seizures less than half as frequently. Four patients developed simple partial motor seizures after callosotomy. A transient disconnection syndrome was observed in 57% of patients. The best predictor of good outcome was a normal preoperative MRI. Mentally retarded patients had poorer outcomes. Outcome was not predicted by extent of callosal section or lateralization on neurological examination, EEG, MRI, and SPECT. Completion of anterior callosotomy resulted in significant reductions in seizure frequency. Though most patients do not become seizure-free after corpus callosotomy, worthwhile palliation of an otherwise intractable illness can be achieved. An analysis of prognostic factors should lead to better selection of patients for surgery.

Original languageEnglish (US)
Pages (from-to)260-267
Number of pages8
JournalPediatric Neurosurgery
Volume27
Issue number5
DOIs
StatePublished - Jan 1 1997

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Seizures
Partial Epilepsy
Corpus Callosum
Mentally Disabled Persons
Neurologic Examination
Single-Photon Emission-Computed Tomography
Patient Selection
Electroencephalography
Morbidity

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Sorenson, J., Wheless, J., Baumgartner, J. E., Thomas, A. B., Brookshire, B. L., L. Clifton, G., & Willmore, J. (1997). Corpus callosotomy for medically intractable seizures. Pediatric Neurosurgery, 27(5), 260-267. https://doi.org/10.1159/000121264

Corpus callosotomy for medically intractable seizures. / Sorenson, Jeffrey; Wheless, James; Baumgartner, James E.; Thomas, Azreena B.; Brookshire, Bonnie L.; L. Clifton, Guy; Willmore, James.

In: Pediatric Neurosurgery, Vol. 27, No. 5, 01.01.1997, p. 260-267.

Research output: Contribution to journalArticle

Sorenson, J, Wheless, J, Baumgartner, JE, Thomas, AB, Brookshire, BL, L. Clifton, G & Willmore, J 1997, 'Corpus callosotomy for medically intractable seizures', Pediatric Neurosurgery, vol. 27, no. 5, pp. 260-267. https://doi.org/10.1159/000121264
Sorenson J, Wheless J, Baumgartner JE, Thomas AB, Brookshire BL, L. Clifton G et al. Corpus callosotomy for medically intractable seizures. Pediatric Neurosurgery. 1997 Jan 1;27(5):260-267. https://doi.org/10.1159/000121264
Sorenson, Jeffrey ; Wheless, James ; Baumgartner, James E. ; Thomas, Azreena B. ; Brookshire, Bonnie L. ; L. Clifton, Guy ; Willmore, James. / Corpus callosotomy for medically intractable seizures. In: Pediatric Neurosurgery. 1997 ; Vol. 27, No. 5. pp. 260-267.
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