Correlates of low hemoglobin A1c in maintenance hemodialysis patients

Youngmee Kim, Jong Chan Park, Miklos Z. Molnar, Anuja Shah, Debbie Benner, Csaba Kovesdy, Joel D. Kopple, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

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Abstract

Purpose: The optimal target for glycemic control has not been established for diabetic maintenance hemodialysis (MHD) patients. Methods: A 6-year cohort (October 2001- December 2006) of 347 diabetic MHD patients with HbA1c data was examined for associations between HbA1c and mortality. Death hazard ratios (HR) were estimated using Cox regressions and cubic splines. Results: In these 347 patients (age, 59 ± 11 years; 49 % women; 28 % African Americans; and 55 % Hispanics), each 0.5 % decline in HbA1c below 6 % was associated with a 4.7 times higher death risk (HR = 4.7; 95 % CI 1.7-12.7) in the fully adjusted model. Factors associated with lower HbA1c levels (<6 % compared to 6-7 %) were: Hispanic ethnicity (OR = 2.9; 95 % CI 1.1-7.9), higher mid-arm muscle circumstance (OR = 1.1; 95 % CI 1.0-1.3), higher total iron-binding capacity (OR = 1.03; 95 % CI 1.01-1.05), and higher iron saturation ratio (OR = 1.14; 95 % CI 1.03-1.26). HbA1c levels >7 % showed a consistent trend toward elevated mortality risk (HR = 1.18; 95 % CI 0.99-1.41) after multivariate adjustment. Conclusions: In diabetic MHD patients with burnt-out diabetes, characterized by HbA1c <6 %, even lower HbA1c levels are associated with significantly higher death risk. Additional studies are needed to determine the optimal target for HbA1c levels in different subgroups of diabetic MHD patients.

Original languageEnglish (US)
Pages (from-to)1079-1090
Number of pages12
JournalInternational Urology and Nephrology
Volume45
Issue number4
DOIs
StatePublished - Aug 1 2013

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Renal Dialysis
Hemoglobins
Maintenance
Odds Ratio
Mortality
Hispanic Americans
African Americans

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Kim, Y., Park, J. C., Molnar, M. Z., Shah, A., Benner, D., Kovesdy, C., ... Kalantar-Zadeh, K. (2013). Correlates of low hemoglobin A1c in maintenance hemodialysis patients. International Urology and Nephrology, 45(4), 1079-1090. https://doi.org/10.1007/s11255-012-0208-y

Correlates of low hemoglobin A1c in maintenance hemodialysis patients. / Kim, Youngmee; Park, Jong Chan; Molnar, Miklos Z.; Shah, Anuja; Benner, Debbie; Kovesdy, Csaba; Kopple, Joel D.; Kalantar-Zadeh, Kamyar.

In: International Urology and Nephrology, Vol. 45, No. 4, 01.08.2013, p. 1079-1090.

Research output: Contribution to journalArticle

Kim, Y, Park, JC, Molnar, MZ, Shah, A, Benner, D, Kovesdy, C, Kopple, JD & Kalantar-Zadeh, K 2013, 'Correlates of low hemoglobin A1c in maintenance hemodialysis patients', International Urology and Nephrology, vol. 45, no. 4, pp. 1079-1090. https://doi.org/10.1007/s11255-012-0208-y
Kim, Youngmee ; Park, Jong Chan ; Molnar, Miklos Z. ; Shah, Anuja ; Benner, Debbie ; Kovesdy, Csaba ; Kopple, Joel D. ; Kalantar-Zadeh, Kamyar. / Correlates of low hemoglobin A1c in maintenance hemodialysis patients. In: International Urology and Nephrology. 2013 ; Vol. 45, No. 4. pp. 1079-1090.
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AU - Park, Jong Chan

AU - Molnar, Miklos Z.

AU - Shah, Anuja

AU - Benner, Debbie

AU - Kovesdy, Csaba

AU - Kopple, Joel D.

AU - Kalantar-Zadeh, Kamyar

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N2 - Purpose: The optimal target for glycemic control has not been established for diabetic maintenance hemodialysis (MHD) patients. Methods: A 6-year cohort (October 2001- December 2006) of 347 diabetic MHD patients with HbA1c data was examined for associations between HbA1c and mortality. Death hazard ratios (HR) were estimated using Cox regressions and cubic splines. Results: In these 347 patients (age, 59 ± 11 years; 49 % women; 28 % African Americans; and 55 % Hispanics), each 0.5 % decline in HbA1c below 6 % was associated with a 4.7 times higher death risk (HR = 4.7; 95 % CI 1.7-12.7) in the fully adjusted model. Factors associated with lower HbA1c levels (<6 % compared to 6-7 %) were: Hispanic ethnicity (OR = 2.9; 95 % CI 1.1-7.9), higher mid-arm muscle circumstance (OR = 1.1; 95 % CI 1.0-1.3), higher total iron-binding capacity (OR = 1.03; 95 % CI 1.01-1.05), and higher iron saturation ratio (OR = 1.14; 95 % CI 1.03-1.26). HbA1c levels >7 % showed a consistent trend toward elevated mortality risk (HR = 1.18; 95 % CI 0.99-1.41) after multivariate adjustment. Conclusions: In diabetic MHD patients with burnt-out diabetes, characterized by HbA1c <6 %, even lower HbA1c levels are associated with significantly higher death risk. Additional studies are needed to determine the optimal target for HbA1c levels in different subgroups of diabetic MHD patients.

AB - Purpose: The optimal target for glycemic control has not been established for diabetic maintenance hemodialysis (MHD) patients. Methods: A 6-year cohort (October 2001- December 2006) of 347 diabetic MHD patients with HbA1c data was examined for associations between HbA1c and mortality. Death hazard ratios (HR) were estimated using Cox regressions and cubic splines. Results: In these 347 patients (age, 59 ± 11 years; 49 % women; 28 % African Americans; and 55 % Hispanics), each 0.5 % decline in HbA1c below 6 % was associated with a 4.7 times higher death risk (HR = 4.7; 95 % CI 1.7-12.7) in the fully adjusted model. Factors associated with lower HbA1c levels (<6 % compared to 6-7 %) were: Hispanic ethnicity (OR = 2.9; 95 % CI 1.1-7.9), higher mid-arm muscle circumstance (OR = 1.1; 95 % CI 1.0-1.3), higher total iron-binding capacity (OR = 1.03; 95 % CI 1.01-1.05), and higher iron saturation ratio (OR = 1.14; 95 % CI 1.03-1.26). HbA1c levels >7 % showed a consistent trend toward elevated mortality risk (HR = 1.18; 95 % CI 0.99-1.41) after multivariate adjustment. Conclusions: In diabetic MHD patients with burnt-out diabetes, characterized by HbA1c <6 %, even lower HbA1c levels are associated with significantly higher death risk. Additional studies are needed to determine the optimal target for HbA1c levels in different subgroups of diabetic MHD patients.

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