Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukaemia

Mary Beth Martin, Chin Shang Li, Christopher C. Rowland, Scott Howard, Sue C. Kaste

Research output: Contribution to journalArticle

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Abstract

Background. There is little information about oncotherapy-related dental development in childhood acute lymphoblastic leukaemia (ALL). Objective. The objective of this study was to compare bone age (BA) and dental age (DA) to chronological age (CA) in childhood ALL survivors. Methods. We retrospectively reviewed hand-wrist and panoramic radiographs of patients treated on contemporary single institution protocols for ALL between 1991 and 2004. We recorded patient demographics, therapeutic protocol, CA, DA, and BA. The cohort was divided into three categories based on age at diagnosis (< 6 years, 6-9 years, > 9 years). Results. Of 73 patients, 39 (53.4%) were boys; 55 (75.3%) were Caucasian. Median CA at diagnosis was 4.5 years (range: 0.1-11.0 years); time to study was 4.1 years (range: 0.3-11.4 years). BA was normal in 61 (83.6%), delayed in 10 (13.7%), and advanced in 2 (2.7%). DA was normal in 41 (56.9%), delayed in 8 (11.1%), and advanced in 23 (31.9%). Abnormal BA, abnormal DA, and discrepancy between BA and DA are not statistically significantly associated with investigated patient or treatment factors. Conclusions. DA may be altered in 43.1% of patients treated for ALL. A large prospective study is warranted to better define our observations and to determine their impact on dental and orthodontic management.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalInternational Journal of Paediatric Dentistry
Volume18
Issue number3
DOIs
StatePublished - May 1 2008

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survivors
Tooth
Bone and Bones
Orthodontics
Wrist
Hand
Demography
Prospective Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukaemia. / Martin, Mary Beth; Li, Chin Shang; Rowland, Christopher C.; Howard, Scott; Kaste, Sue C.

In: International Journal of Paediatric Dentistry, Vol. 18, No. 3, 01.05.2008, p. 217-223.

Research output: Contribution to journalArticle

Martin, Mary Beth ; Li, Chin Shang ; Rowland, Christopher C. ; Howard, Scott ; Kaste, Sue C. / Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukaemia. In: International Journal of Paediatric Dentistry. 2008 ; Vol. 18, No. 3. pp. 217-223.
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