Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension

Thomas D. Giles, George Bakris, Suzanne Oparil, Michael A. Weber, Huiling Li, Madhuja Mallick, David B. Bharucha, Chunlin Chen, William G. Ferguson, John Sorin, Matthew Davis, Joesph Izzo, Nabile Andrawis, Alyn Anderson, Rogelio Bardinas-Rodriguez, Douglas Young, Andrew Schreiber, Cristian Breton, Duane Harris, Phillip Lastella & 106 others Ramon Castello, Susan Hole, Joesph Lillo, Luis Carlos Quintero, Carlos Montenegro, Jeffrey Rosen, Farid Marquez, Fredric Adler, Sady Alpizar, James Andersen, Corey Anderson, Graciela Calatayud, Kevin Cannon, Deanna Cheung, Rafel Chiong, Lisa Cohen, Harry Collins, Michael Dao, Cara H. Dawson, Donna Desantis, Shelly Dunmyer, Sherif El-Harazi, Cecil M. Farrington, David Ferrera, Gregory S. Funk, Gregory Gottschlich, Terence T. Hart, Marvin Kalafer, Dean Kereiakes, Gigi Lefebvre, Aristolis Laliotis, Peter Mattar, Michael McCartney, Diane McConnehey, Curtis Mello, Joel Neutel, Deborah A. Burke, James Pritchard, George Raad, Bruce Rankin, John H. Reed, Erich Schramm, Howard Schwartz, Nathan Segall, James Shoemaker, Vakas Sial, Teresa Sligh, William Smith, Richard Stewart, Dan Streja, Danny Sugimoto, Alexander White, Hayes Williams, William Abraham, Azazuddin Ahmed, Richard Beasley, Daniel Gruener, Connie Hsu, Ryan Klein, Allen Soo, Charles P. Andrews, Clinton Corder, Donald Hurley, Elizabeth Bretton, Richard Martinez, David Morin, Miguel Trevino, Samir Arora, Curtis Scott Horn, Charles Lovell, Thomas Nussdorfer, Robert Weiss, Harold Bays, Jackson Rhudy, Edwardo Almaguer, Joseph H. Woolley, Vicki Miller, Jaynier Moya-Hechevarria, Henry Punzi, Addison Taylor, Jonathan Wilson, Arnold Alper, Patricia Buchanan, Richard Dobrusin, Alan Forker, Razmig Krumian, Samuel F. Oberstein, Andrew Lewin, Mary Bella Natividad, Armando Segui, Wayne Harper, Andrea Lawless, Lawrence S. Levinson, Shaukat Shah, Loray Blair-Britt, Patrick Carmichael, Nathaniel Winer, David Grant, Kyle Rickner, Absalom Tilley, Linda Harper, Stephen Maddock, Joseph A. Boscia, Yekaterina Khronusova, Larry D. Reed, Chandar Abboy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

After demonstration of the antihypertensive efficacy of the combination of the beta-blocker nebivolol and the angiotensin receptor blocker valsartan in an 8-week, randomized, placebo-controlled trial (N = 4161), we now report the effects of this treatment on the renin-angiotensin-aldosterone system in a substudy (n = 805). Plasma renin activity increased with valsartan (54%-73%) and decreased with nebivolol (51%-65%) and the combination treatment (17%-39%). Plasma aldosterone decreased with individual treatments (valsartan, 11%-22%; nebivolol, 20%-26%), with the largest reduction (35%) observed with maximum combination dose (20 mg nebivolol/320 mg valsartan). Baseline ln(plasma renin activity) correlated with the 8-week reductions in 24-hour systolic and diastolic BP following treatments with the combination (all doses combined, P =.003 and P <.001) and nebivolol (both, P <.001), but not with valsartan. Baseline ln(aldosterone) correlated with 24-hour systolic and diastolic BP reductions following combination treatment only (P <.001 and P =.005). The implications of the renin-angiotensin-aldosterone system effects of this beta blocker-angiotensin receptor blocker combination should be explored further.

Original languageEnglish (US)
Pages (from-to)845-854
Number of pages10
JournalJournal of the American Society of Hypertension
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2015

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Nebivolol
Valsartan
Aldosterone
Renin
Blood Pressure
Hypertension
Angiotensin Receptor Antagonists
Renin-Angiotensin System
Therapeutics
Antihypertensive Agents
Randomized Controlled Trials
Placebos

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension. / Giles, Thomas D.; Bakris, George; Oparil, Suzanne; Weber, Michael A.; Li, Huiling; Mallick, Madhuja; Bharucha, David B.; Chen, Chunlin; Ferguson, William G.; Sorin, John; Davis, Matthew; Izzo, Joesph; Andrawis, Nabile; Anderson, Alyn; Bardinas-Rodriguez, Rogelio; Young, Douglas; Schreiber, Andrew; Breton, Cristian; Harris, Duane; Lastella, Phillip; Castello, Ramon; Hole, Susan; Lillo, Joesph; Quintero, Luis Carlos; Montenegro, Carlos; Rosen, Jeffrey; Marquez, Farid; Adler, Fredric; Alpizar, Sady; Andersen, James; Anderson, Corey; Calatayud, Graciela; Cannon, Kevin; Cheung, Deanna; Chiong, Rafel; Cohen, Lisa; Collins, Harry; Dao, Michael; Dawson, Cara H.; Desantis, Donna; Dunmyer, Shelly; El-Harazi, Sherif; Farrington, Cecil M.; Ferrera, David; Funk, Gregory S.; Gottschlich, Gregory; Hart, Terence T.; Kalafer, Marvin; Kereiakes, Dean; Lefebvre, Gigi; Laliotis, Aristolis; Mattar, Peter; McCartney, Michael; McConnehey, Diane; Mello, Curtis; Neutel, Joel; Burke, Deborah A.; Pritchard, James; Raad, George; Rankin, Bruce; Reed, John H.; Schramm, Erich; Schwartz, Howard; Segall, Nathan; Shoemaker, James; Sial, Vakas; Sligh, Teresa; Smith, William; Stewart, Richard; Streja, Dan; Sugimoto, Danny; White, Alexander; Williams, Hayes; Abraham, William; Ahmed, Azazuddin; Beasley, Richard; Gruener, Daniel; Hsu, Connie; Klein, Ryan; Soo, Allen; Andrews, Charles P.; Corder, Clinton; Hurley, Donald; Bretton, Elizabeth; Martinez, Richard; Morin, David; Trevino, Miguel; Arora, Samir; Horn, Curtis Scott; Lovell, Charles; Nussdorfer, Thomas; Weiss, Robert; Bays, Harold; Rhudy, Jackson; Almaguer, Edwardo; Woolley, Joseph H.; Miller, Vicki; Moya-Hechevarria, Jaynier; Punzi, Henry; Taylor, Addison; Wilson, Jonathan; Alper, Arnold; Buchanan, Patricia; Dobrusin, Richard; Forker, Alan; Krumian, Razmig; Oberstein, Samuel F.; Lewin, Andrew; Natividad, Mary Bella; Segui, Armando; Harper, Wayne; Lawless, Andrea; Levinson, Lawrence S.; Shah, Shaukat; Blair-Britt, Loray; Carmichael, Patrick; Winer, Nathaniel; Grant, David; Rickner, Kyle; Tilley, Absalom; Harper, Linda; Maddock, Stephen; Boscia, Joseph A.; Khronusova, Yekaterina; Reed, Larry D.; Abboy, Chandar.

In: Journal of the American Society of Hypertension, Vol. 9, No. 11, 01.11.2015, p. 845-854.

Research output: Contribution to journalArticle

Giles, TD, Bakris, G, Oparil, S, Weber, MA, Li, H, Mallick, M, Bharucha, DB, Chen, C, Ferguson, WG, Sorin, J, Davis, M, Izzo, J, Andrawis, N, Anderson, A, Bardinas-Rodriguez, R, Young, D, Schreiber, A, Breton, C, Harris, D, Lastella, P, Castello, R, Hole, S, Lillo, J, Quintero, LC, Montenegro, C, Rosen, J, Marquez, F, Adler, F, Alpizar, S, Andersen, J, Anderson, C, Calatayud, G, Cannon, K, Cheung, D, Chiong, R, Cohen, L, Collins, H, Dao, M, Dawson, CH, Desantis, D, Dunmyer, S, El-Harazi, S, Farrington, CM, Ferrera, D, Funk, GS, Gottschlich, G, Hart, TT, Kalafer, M, Kereiakes, D, Lefebvre, G, Laliotis, A, Mattar, P, McCartney, M, McConnehey, D, Mello, C, Neutel, J, Burke, DA, Pritchard, J, Raad, G, Rankin, B, Reed, JH, Schramm, E, Schwartz, H, Segall, N, Shoemaker, J, Sial, V, Sligh, T, Smith, W, Stewart, R, Streja, D, Sugimoto, D, White, A, Williams, H, Abraham, W, Ahmed, A, Beasley, R, Gruener, D, Hsu, C, Klein, R, Soo, A, Andrews, CP, Corder, C, Hurley, D, Bretton, E, Martinez, R, Morin, D, Trevino, M, Arora, S, Horn, CS, Lovell, C, Nussdorfer, T, Weiss, R, Bays, H, Rhudy, J, Almaguer, E, Woolley, JH, Miller, V, Moya-Hechevarria, J, Punzi, H, Taylor, A, Wilson, J, Alper, A, Buchanan, P, Dobrusin, R, Forker, A, Krumian, R, Oberstein, SF, Lewin, A, Natividad, MB, Segui, A, Harper, W, Lawless, A, Levinson, LS, Shah, S, Blair-Britt, L, Carmichael, P, Winer, N, Grant, D, Rickner, K, Tilley, A, Harper, L, Maddock, S, Boscia, JA, Khronusova, Y, Reed, LD & Abboy, C 2015, 'Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension', Journal of the American Society of Hypertension, vol. 9, no. 11, pp. 845-854. https://doi.org/10.1016/j.jash.2015.08.003
Giles, Thomas D. ; Bakris, George ; Oparil, Suzanne ; Weber, Michael A. ; Li, Huiling ; Mallick, Madhuja ; Bharucha, David B. ; Chen, Chunlin ; Ferguson, William G. ; Sorin, John ; Davis, Matthew ; Izzo, Joesph ; Andrawis, Nabile ; Anderson, Alyn ; Bardinas-Rodriguez, Rogelio ; Young, Douglas ; Schreiber, Andrew ; Breton, Cristian ; Harris, Duane ; Lastella, Phillip ; Castello, Ramon ; Hole, Susan ; Lillo, Joesph ; Quintero, Luis Carlos ; Montenegro, Carlos ; Rosen, Jeffrey ; Marquez, Farid ; Adler, Fredric ; Alpizar, Sady ; Andersen, James ; Anderson, Corey ; Calatayud, Graciela ; Cannon, Kevin ; Cheung, Deanna ; Chiong, Rafel ; Cohen, Lisa ; Collins, Harry ; Dao, Michael ; Dawson, Cara H. ; Desantis, Donna ; Dunmyer, Shelly ; El-Harazi, Sherif ; Farrington, Cecil M. ; Ferrera, David ; Funk, Gregory S. ; Gottschlich, Gregory ; Hart, Terence T. ; Kalafer, Marvin ; Kereiakes, Dean ; Lefebvre, Gigi ; Laliotis, Aristolis ; Mattar, Peter ; McCartney, Michael ; McConnehey, Diane ; Mello, Curtis ; Neutel, Joel ; Burke, Deborah A. ; Pritchard, James ; Raad, George ; Rankin, Bruce ; Reed, John H. ; Schramm, Erich ; Schwartz, Howard ; Segall, Nathan ; Shoemaker, James ; Sial, Vakas ; Sligh, Teresa ; Smith, William ; Stewart, Richard ; Streja, Dan ; Sugimoto, Danny ; White, Alexander ; Williams, Hayes ; Abraham, William ; Ahmed, Azazuddin ; Beasley, Richard ; Gruener, Daniel ; Hsu, Connie ; Klein, Ryan ; Soo, Allen ; Andrews, Charles P. ; Corder, Clinton ; Hurley, Donald ; Bretton, Elizabeth ; Martinez, Richard ; Morin, David ; Trevino, Miguel ; Arora, Samir ; Horn, Curtis Scott ; Lovell, Charles ; Nussdorfer, Thomas ; Weiss, Robert ; Bays, Harold ; Rhudy, Jackson ; Almaguer, Edwardo ; Woolley, Joseph H. ; Miller, Vicki ; Moya-Hechevarria, Jaynier ; Punzi, Henry ; Taylor, Addison ; Wilson, Jonathan ; Alper, Arnold ; Buchanan, Patricia ; Dobrusin, Richard ; Forker, Alan ; Krumian, Razmig ; Oberstein, Samuel F. ; Lewin, Andrew ; Natividad, Mary Bella ; Segui, Armando ; Harper, Wayne ; Lawless, Andrea ; Levinson, Lawrence S. ; Shah, Shaukat ; Blair-Britt, Loray ; Carmichael, Patrick ; Winer, Nathaniel ; Grant, David ; Rickner, Kyle ; Tilley, Absalom ; Harper, Linda ; Maddock, Stephen ; Boscia, Joseph A. ; Khronusova, Yekaterina ; Reed, Larry D. ; Abboy, Chandar. / Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension. In: Journal of the American Society of Hypertension. 2015 ; Vol. 9, No. 11. pp. 845-854.
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title = "Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension",
abstract = "After demonstration of the antihypertensive efficacy of the combination of the beta-blocker nebivolol and the angiotensin receptor blocker valsartan in an 8-week, randomized, placebo-controlled trial (N = 4161), we now report the effects of this treatment on the renin-angiotensin-aldosterone system in a substudy (n = 805). Plasma renin activity increased with valsartan (54{\%}-73{\%}) and decreased with nebivolol (51{\%}-65{\%}) and the combination treatment (17{\%}-39{\%}). Plasma aldosterone decreased with individual treatments (valsartan, 11{\%}-22{\%}; nebivolol, 20{\%}-26{\%}), with the largest reduction (35{\%}) observed with maximum combination dose (20 mg nebivolol/320 mg valsartan). Baseline ln(plasma renin activity) correlated with the 8-week reductions in 24-hour systolic and diastolic BP following treatments with the combination (all doses combined, P =.003 and P <.001) and nebivolol (both, P <.001), but not with valsartan. Baseline ln(aldosterone) correlated with 24-hour systolic and diastolic BP reductions following combination treatment only (P <.001 and P =.005). The implications of the renin-angiotensin-aldosterone system effects of this beta blocker-angiotensin receptor blocker combination should be explored further.",
author = "Giles, {Thomas D.} and George Bakris and Suzanne Oparil and Weber, {Michael A.} and Huiling Li and Madhuja Mallick and Bharucha, {David B.} and Chunlin Chen and Ferguson, {William G.} and John Sorin and Matthew Davis and Joesph Izzo and Nabile Andrawis and Alyn Anderson and Rogelio Bardinas-Rodriguez and Douglas Young and Andrew Schreiber and Cristian Breton and Duane Harris and Phillip Lastella and Ramon Castello and Susan Hole and Joesph Lillo and Quintero, {Luis Carlos} and Carlos Montenegro and Jeffrey Rosen and Farid Marquez and Fredric Adler and Sady Alpizar and James Andersen and Corey Anderson and Graciela Calatayud and Kevin Cannon and Deanna Cheung and Rafel Chiong and Lisa Cohen and Harry Collins and Michael Dao and Dawson, {Cara H.} and Donna Desantis and Shelly Dunmyer and Sherif El-Harazi and Farrington, {Cecil M.} and David Ferrera and Funk, {Gregory S.} and Gregory Gottschlich and Hart, {Terence T.} and Marvin Kalafer and Dean Kereiakes and Gigi Lefebvre and Aristolis Laliotis and Peter Mattar and Michael McCartney and Diane McConnehey and Curtis Mello and Joel Neutel and Burke, {Deborah A.} and James Pritchard and George Raad and Bruce Rankin and Reed, {John H.} and Erich Schramm and Howard Schwartz and Nathan Segall and James Shoemaker and Vakas Sial and Teresa Sligh and William Smith and Richard Stewart and Dan Streja and Danny Sugimoto and Alexander White and Hayes Williams and William Abraham and Azazuddin Ahmed and Richard Beasley and Daniel Gruener and Connie Hsu and Ryan Klein and Allen Soo and Andrews, {Charles P.} and Clinton Corder and Donald Hurley and Elizabeth Bretton and Richard Martinez and David Morin and Miguel Trevino and Samir Arora and Horn, {Curtis Scott} and Charles Lovell and Thomas Nussdorfer and Robert Weiss and Harold Bays and Jackson Rhudy and Edwardo Almaguer and Woolley, {Joseph H.} and Vicki Miller and Jaynier Moya-Hechevarria and Henry Punzi and Addison Taylor and Jonathan Wilson and Arnold Alper and Patricia Buchanan and Richard Dobrusin and Alan Forker and Razmig Krumian and Oberstein, {Samuel F.} and Andrew Lewin and Natividad, {Mary Bella} and Armando Segui and Wayne Harper and Andrea Lawless and Levinson, {Lawrence S.} and Shaukat Shah and Loray Blair-Britt and Patrick Carmichael and Nathaniel Winer and David Grant and Kyle Rickner and Absalom Tilley and Linda Harper and Stephen Maddock and Boscia, {Joseph A.} and Yekaterina Khronusova and Reed, {Larry D.} and Chandar Abboy",
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T1 - Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension

AU - Giles, Thomas D.

AU - Bakris, George

AU - Oparil, Suzanne

AU - Weber, Michael A.

AU - Li, Huiling

AU - Mallick, Madhuja

AU - Bharucha, David B.

AU - Chen, Chunlin

AU - Ferguson, William G.

AU - Sorin, John

AU - Davis, Matthew

AU - Izzo, Joesph

AU - Andrawis, Nabile

AU - Anderson, Alyn

AU - Bardinas-Rodriguez, Rogelio

AU - Young, Douglas

AU - Schreiber, Andrew

AU - Breton, Cristian

AU - Harris, Duane

AU - Lastella, Phillip

AU - Castello, Ramon

AU - Hole, Susan

AU - Lillo, Joesph

AU - Quintero, Luis Carlos

AU - Montenegro, Carlos

AU - Rosen, Jeffrey

AU - Marquez, Farid

AU - Adler, Fredric

AU - Alpizar, Sady

AU - Andersen, James

AU - Anderson, Corey

AU - Calatayud, Graciela

AU - Cannon, Kevin

AU - Cheung, Deanna

AU - Chiong, Rafel

AU - Cohen, Lisa

AU - Collins, Harry

AU - Dao, Michael

AU - Dawson, Cara H.

AU - Desantis, Donna

AU - Dunmyer, Shelly

AU - El-Harazi, Sherif

AU - Farrington, Cecil M.

AU - Ferrera, David

AU - Funk, Gregory S.

AU - Gottschlich, Gregory

AU - Hart, Terence T.

AU - Kalafer, Marvin

AU - Kereiakes, Dean

AU - Lefebvre, Gigi

AU - Laliotis, Aristolis

AU - Mattar, Peter

AU - McCartney, Michael

AU - McConnehey, Diane

AU - Mello, Curtis

AU - Neutel, Joel

AU - Burke, Deborah A.

AU - Pritchard, James

AU - Raad, George

AU - Rankin, Bruce

AU - Reed, John H.

AU - Schramm, Erich

AU - Schwartz, Howard

AU - Segall, Nathan

AU - Shoemaker, James

AU - Sial, Vakas

AU - Sligh, Teresa

AU - Smith, William

AU - Stewart, Richard

AU - Streja, Dan

AU - Sugimoto, Danny

AU - White, Alexander

AU - Williams, Hayes

AU - Abraham, William

AU - Ahmed, Azazuddin

AU - Beasley, Richard

AU - Gruener, Daniel

AU - Hsu, Connie

AU - Klein, Ryan

AU - Soo, Allen

AU - Andrews, Charles P.

AU - Corder, Clinton

AU - Hurley, Donald

AU - Bretton, Elizabeth

AU - Martinez, Richard

AU - Morin, David

AU - Trevino, Miguel

AU - Arora, Samir

AU - Horn, Curtis Scott

AU - Lovell, Charles

AU - Nussdorfer, Thomas

AU - Weiss, Robert

AU - Bays, Harold

AU - Rhudy, Jackson

AU - Almaguer, Edwardo

AU - Woolley, Joseph H.

AU - Miller, Vicki

AU - Moya-Hechevarria, Jaynier

AU - Punzi, Henry

AU - Taylor, Addison

AU - Wilson, Jonathan

AU - Alper, Arnold

AU - Buchanan, Patricia

AU - Dobrusin, Richard

AU - Forker, Alan

AU - Krumian, Razmig

AU - Oberstein, Samuel F.

AU - Lewin, Andrew

AU - Natividad, Mary Bella

AU - Segui, Armando

AU - Harper, Wayne

AU - Lawless, Andrea

AU - Levinson, Lawrence S.

AU - Shah, Shaukat

AU - Blair-Britt, Loray

AU - Carmichael, Patrick

AU - Winer, Nathaniel

AU - Grant, David

AU - Rickner, Kyle

AU - Tilley, Absalom

AU - Harper, Linda

AU - Maddock, Stephen

AU - Boscia, Joseph A.

AU - Khronusova, Yekaterina

AU - Reed, Larry D.

AU - Abboy, Chandar

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N2 - After demonstration of the antihypertensive efficacy of the combination of the beta-blocker nebivolol and the angiotensin receptor blocker valsartan in an 8-week, randomized, placebo-controlled trial (N = 4161), we now report the effects of this treatment on the renin-angiotensin-aldosterone system in a substudy (n = 805). Plasma renin activity increased with valsartan (54%-73%) and decreased with nebivolol (51%-65%) and the combination treatment (17%-39%). Plasma aldosterone decreased with individual treatments (valsartan, 11%-22%; nebivolol, 20%-26%), with the largest reduction (35%) observed with maximum combination dose (20 mg nebivolol/320 mg valsartan). Baseline ln(plasma renin activity) correlated with the 8-week reductions in 24-hour systolic and diastolic BP following treatments with the combination (all doses combined, P =.003 and P <.001) and nebivolol (both, P <.001), but not with valsartan. Baseline ln(aldosterone) correlated with 24-hour systolic and diastolic BP reductions following combination treatment only (P <.001 and P =.005). The implications of the renin-angiotensin-aldosterone system effects of this beta blocker-angiotensin receptor blocker combination should be explored further.

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