Cortical 5HT2A receptor function under hypoxia in neonatal rats

Role of glucose, oxygen, and epinephrine resuscitation

T. R. Anju, S. Smijin, Korah Pushpamangalam Kuruvilla, C. S. Paulose

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neonatal hypoxia induces brain injury through alterations in neurotransmitters and its receptors. Molecular processes regulating serotonergic receptors play an important role in the control of respiration under hypoxia. The present study evaluates the serotonergic regulation of neonatal hypoxia and its resuscitation methods. Receptor binding assays and gene expression studies were done to evaluate the changes in 5HT2A receptors and its transporter in the cerebral cortex of hypoxic neonatal rats and hypoxic rats resuscitated with glucose, oxygen, and epinephrine. Hypoxic stress increased total 5HT and 5HT2A receptor number along with an upregulation of 5HT2A receptor and 5HT transporter gene in the cortex. The enhanced cortical 5HT2A receptors may act as a modulator of ventilatory response to hypoxia. These alterations were reversed to near control by glucose supplementation. Glucose supplementation helped in managing the serotonergic functional alterations. Hypoxia-induced adenosine triphosphate depletion causes a reduction in blood glucose levels which can be encountered by glucose administration, and oxygenation helps in overcoming the anaerobic condition. The adverse effect of immediate oxygenation and epinephrine supplementation was also reported. This has immense clinical significance in establishing a proper resuscitation for the management of neonatal hypoxia.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalJournal of Molecular Neuroscience
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2011

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Resuscitation
Epinephrine
Oxygen
Glucose
Serotonin Plasma Membrane Transport Proteins
Neurotransmitter Receptor
Cerebral Cortex
Brain Injuries
Blood Glucose
Hypoxia
Respiration
Up-Regulation
Adenosine Triphosphate
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Cortical 5HT2A receptor function under hypoxia in neonatal rats : Role of glucose, oxygen, and epinephrine resuscitation. / Anju, T. R.; Smijin, S.; Pushpamangalam Kuruvilla, Korah; Paulose, C. S.

In: Journal of Molecular Neuroscience, Vol. 43, No. 3, 01.03.2011, p. 350-357.

Research output: Contribution to journalArticle

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