Covalent Structure of Collagen

Amino Acid Sequence of α1-CB3 of Chick Skin Collagen

S. N. Dixit, Andrew Kang, J. Gross

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The amino acid sequence of α1-CB3, a peptide containing 149 residues obtained from the central portion of the α 1(1) chain of chick skin collagen by cyanogen bromide cleavage, has been determined. As in the other sequences from the helical region of collagen chains, the repeating triplet Gly-X-Y extends throughout the length of the peptide. These data allow a comparison of the sequence to that of α1-CB3 from calf and rat skin collagens. As compared with calf, the chick peptide contains 14 amino acid differences, whereas it contains 17 residue differences from the rat peptide. Thus, the sequence identity level is 91 and 89%, respectively, in comparison to the calf and rat peptides. These values are significantly greater than the value of 97% observed between the peptide of the two mammalian species and reflect the greater phylogenetic distance of the species compared.

Original languageEnglish (US)
Pages (from-to)1929-1933
Number of pages5
JournalBiochemistry
Volume14
Issue number9
DOIs
StatePublished - May 1 1975

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Amino Acid Sequence
Skin
Collagen
Amino Acids
Peptides
Rats
Cyanogen Bromide

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Covalent Structure of Collagen : Amino Acid Sequence of α1-CB3 of Chick Skin Collagen. / Dixit, S. N.; Kang, Andrew; Gross, J.

In: Biochemistry, Vol. 14, No. 9, 01.05.1975, p. 1929-1933.

Research output: Contribution to journalArticle

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