cPSA and fPSA elimination in African-American men

B. J. Martin, C. Cheli, R. Davis, M. Ward, M. Kokatnur, D. Mercante, D. Lifsey, Walter Rayford

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an α-phase elimination of 0.50 h and a β-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume6
Issue number2
DOIs
StatePublished - Jul 15 2003
Externally publishedYes

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African Americans
Half-Life
Prostatectomy
Prostate
Adenocarcinoma
Serum
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology
  • Cancer Research

Cite this

Martin, B. J., Cheli, C., Davis, R., Ward, M., Kokatnur, M., Mercante, D., ... Rayford, W. (2003). cPSA and fPSA elimination in African-American men. Prostate Cancer and Prostatic Diseases, 6(2), 163-168. https://doi.org/10.1038/sj.pcan.4500649

cPSA and fPSA elimination in African-American men. / Martin, B. J.; Cheli, C.; Davis, R.; Ward, M.; Kokatnur, M.; Mercante, D.; Lifsey, D.; Rayford, Walter.

In: Prostate Cancer and Prostatic Diseases, Vol. 6, No. 2, 15.07.2003, p. 163-168.

Research output: Contribution to journalArticle

Martin, BJ, Cheli, C, Davis, R, Ward, M, Kokatnur, M, Mercante, D, Lifsey, D & Rayford, W 2003, 'cPSA and fPSA elimination in African-American men', Prostate Cancer and Prostatic Diseases, vol. 6, no. 2, pp. 163-168. https://doi.org/10.1038/sj.pcan.4500649
Martin BJ, Cheli C, Davis R, Ward M, Kokatnur M, Mercante D et al. cPSA and fPSA elimination in African-American men. Prostate Cancer and Prostatic Diseases. 2003 Jul 15;6(2):163-168. https://doi.org/10.1038/sj.pcan.4500649
Martin, B. J. ; Cheli, C. ; Davis, R. ; Ward, M. ; Kokatnur, M. ; Mercante, D. ; Lifsey, D. ; Rayford, Walter. / cPSA and fPSA elimination in African-American men. In: Prostate Cancer and Prostatic Diseases. 2003 ; Vol. 6, No. 2. pp. 163-168.
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