CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans

Chang Hoon Jee, Jimmy F. Goncalves, Brigitte LeBoeuf, L. Rene Garcia

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Environmental conditions can modulate innate behaviours. Although male Caenorhabditis elegans copulation can be perturbed in the presence of stress, the mechanisms underlying its decision to sustain copulation are unclear. Here we describe a mating interference assay, which quantifies the persistence of male C. elegans copulation in noxious blue light. We show that between copulations, the male escapes from blue light illumination at intensities over 370 μW mm-2. This response is attenuated in mutants with constitutive activation of the corticotropin-releasing factor receptor family homologue SEB-3. We show that activation of this receptor causes sex-common glutamatergic lumbar ganglion interneurons (LUA) to potentiate downstream male-specific reproduction circuits, allowing copulatory behaviours to partially override the light-induced escape responses in the male. SEB-3 activation in LUA also potentiates copulation during mild starvation. We suggest that SEB-3 activation allows C. elegans to acclimate to the environment and thus continue to execute innate behaviours even under non-optimal conditions.

Original languageEnglish (US)
Article number11957
JournalNature Communications
Volume7
DOIs
StatePublished - Jun 20 2016

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Corticotropin-Releasing Hormone Receptors
Copulation
Interneurons
Chemical activation
Caenorhabditis elegans
activation
Instinct
Light
escape
releasing
Assays
Starvation
Lighting
Ganglia
Reproduction
illumination
Handling (Psychology)
Drive
Networks (circuits)
interference

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans. / Jee, Chang Hoon; Goncalves, Jimmy F.; LeBoeuf, Brigitte; Garcia, L. Rene.

In: Nature Communications, Vol. 7, 11957, 20.06.2016.

Research output: Contribution to journalReview article

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