CRH inhibits NF-κB signaling in human melanocytes

Blazej Zbytek, Lawrence Pfeffer, Andrzej T. Slominski

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Corticotropin releasing hormone (CRH), a messenger of stress at the central level, is expressed in the epidermis where it operates within local equivalent of hypothalamo-pituitary axis. CRH inhibits NF-κB activity in human immortalized epidermal (PIG1) melanocytes. In melanocytes CRH stimulates pro-opiomelanocortin (POMC) mRNA and adrenocorticotropin (ACTH) peptide production. Knockdown of POMC levels by transfecting cells with antisense oligonucleotides blocks the effect of CRH on NF-κB signaling indicating that the above inhibition is indirect, e.g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin.

Original languageEnglish (US)
Pages (from-to)3276-3283
Number of pages8
JournalPeptides
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2006

Fingerprint

Pro-Opiomelanocortin
Melanocytes
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Antisense Oligonucleotides
Hormones
Epidermis
Human Activities
Skin
Chemical activation
Feedback
Messenger RNA
Peptides

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

CRH inhibits NF-κB signaling in human melanocytes. / Zbytek, Blazej; Pfeffer, Lawrence; Slominski, Andrzej T.

In: Peptides, Vol. 27, No. 12, 01.12.2006, p. 3276-3283.

Research output: Contribution to journalArticle

Zbytek, Blazej ; Pfeffer, Lawrence ; Slominski, Andrzej T. / CRH inhibits NF-κB signaling in human melanocytes. In: Peptides. 2006 ; Vol. 27, No. 12. pp. 3276-3283.
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