Cross-kingdom interactions: Candida albicans and bacteria

Mark E. Shirtliff, Brian Peters, Mary Ann Jabra-Rizk

Research output: Contribution to journalShort survey

202 Citations (Scopus)

Abstract

Bacteria and fungi are found together in a myriad of environments and particularly in a biofilm, where adherent species interact through diverse signaling mechanisms. Yet, despite billions of years of coexistence, the area of research exploring fungal-bacterial interactions, particularly within the context of polymicrobial infections, is still in its infancy. However, reports describing a multitude of wide-ranging interactions between the fungal pathogen Candida albicans and various bacterial pathogens are on the rise. An example of a mutually beneficial interaction is coaggregation, a phenomenon that takes place in oral biofilms where the adhesion of C. albicans to oral bacteria is considered crucial for its colonization of the oral cavity. In contrast, the interaction between C. albicans and Pseudomonas aeruginosa is described as being competitive and antagonistic in nature. Another intriguing interaction is that occurring between Staphylococcus aureus and C. albicans, which although not yet fully characterized, appears to be initially synergistic. These complex interactions between such diverse and important pathogens would have significant clinical implications if they occurred in an immunocompromised host. Therefore, understanding the mechanisms of adhesion and signaling involved in fungal-bacterial interactions may lead to the development of novel therapeutic strategies for impeding microbial colonization and development of polymicrobial disease.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalFEMS Microbiology Letters
Volume299
Issue number1
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Candida albicans
Bacteria
Biofilms
Immunocompromised Host
Coinfection
Pseudomonas aeruginosa
Mouth
Staphylococcus aureus
Fungi
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Genetics
  • Molecular Biology

Cite this

Cross-kingdom interactions : Candida albicans and bacteria. / Shirtliff, Mark E.; Peters, Brian; Jabra-Rizk, Mary Ann.

In: FEMS Microbiology Letters, Vol. 299, No. 1, 01.10.2009, p. 1-8.

Research output: Contribution to journalShort survey

Shirtliff, Mark E. ; Peters, Brian ; Jabra-Rizk, Mary Ann. / Cross-kingdom interactions : Candida albicans and bacteria. In: FEMS Microbiology Letters. 2009 ; Vol. 299, No. 1. pp. 1-8.
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