Cross-reactivity between immunodominant human T lymphotropic virus type I tax and neurons

Implications for molecular mimicry

Michael C. Levin, Sang Lee, Yvette Morcos, John Brady, John Stuart

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is associated with immunoreactivity to HTLV-I tax. Antibodies isolated from patients with HAM/TSP and monoclonal antibodies (MAbs) to HTLV-I tax stained neurons. In neuronal extracts, HAM/TSP immunoglobulin G identified heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as the autoantigen. Importantly, tax MAbs reacted with hnRNP A1. To identify the epitope recognized by the tax MAbs, the fine epitope specificity of the antibodies was determined using overlapping peptides. This analysis identified an epitope at the C-terminus (tax 346-353 ), which overlaps a human immunodominant domain. Preincubation of this peptide with tax MAbs inhibited antibody binding to tax, hnRNP A1, and neurons. This indicates that a cross-reactive immune response between HTLV-I tax and neuronal hnRNP A1 is contained within the human immunodominant epitope of tax and suggests that molecular mimicry plays a role in the pathogenesis of HAM/TSP.

Original languageEnglish (US)
Pages (from-to)1514-1517
Number of pages4
JournalJournal of Infectious Diseases
Volume186
Issue number10
DOIs
StatePublished - Nov 15 2002

Fingerprint

Molecular Mimicry
Tropical Spastic Paraparesis
Heterogeneous-Nuclear Ribonucleoproteins
Viruses
Neurons
Monoclonal Antibodies
Epitopes
Immunodominant Epitopes
Antibody Specificity
Antibodies
Spinal Cord Diseases
Autoantigens
Immunoglobulin G
Peptides

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Cross-reactivity between immunodominant human T lymphotropic virus type I tax and neurons : Implications for molecular mimicry. / Levin, Michael C.; Lee, Sang; Morcos, Yvette; Brady, John; Stuart, John.

In: Journal of Infectious Diseases, Vol. 186, No. 10, 15.11.2002, p. 1514-1517.

Research output: Contribution to journalArticle

Levin, Michael C. ; Lee, Sang ; Morcos, Yvette ; Brady, John ; Stuart, John. / Cross-reactivity between immunodominant human T lymphotropic virus type I tax and neurons : Implications for molecular mimicry. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 10. pp. 1514-1517.
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