Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk

Sang Ah Lee, Jay Fowke, Wei Lu, Chuangzhong Ye, Ying Zheng, Qiuyin Cai, Kai Gu, Yu Tang Gao, Xiao Ou Shu, Wei Zheng

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs). Objective: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile105Val genetic polymorphism on breast cancer risk. Design: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87% of cases and 85% of controls). Results: With the use of multivariate logistic regression, the GSTP1 Val/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95% CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95% CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95% CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend < 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95% CI: 1.13, 2.67) that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95% CI = 1.20, 3.59). Conclusions: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number3
StatePublished - Mar 1 2008
Externally publishedYes

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Genetic Polymorphisms
Vegetables
Breast Neoplasms
Genotype
Isothiocyanates
Glucosinolates
Brassica napus
Population Control
Brassica
Glutathione Transferase
Logistic Models
Diet
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk. / Lee, Sang Ah; Fowke, Jay; Lu, Wei; Ye, Chuangzhong; Zheng, Ying; Cai, Qiuyin; Gu, Kai; Gao, Yu Tang; Shu, Xiao Ou; Zheng, Wei.

In: American Journal of Clinical Nutrition, Vol. 87, No. 3, 01.03.2008, p. 753-760.

Research output: Contribution to journalArticle

Lee, SA, Fowke, J, Lu, W, Ye, C, Zheng, Y, Cai, Q, Gu, K, Gao, YT, Shu, XO & Zheng, W 2008, 'Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk', American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 753-760.
Lee, Sang Ah ; Fowke, Jay ; Lu, Wei ; Ye, Chuangzhong ; Zheng, Ying ; Cai, Qiuyin ; Gu, Kai ; Gao, Yu Tang ; Shu, Xiao Ou ; Zheng, Wei. / Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk. In: American Journal of Clinical Nutrition. 2008 ; Vol. 87, No. 3. pp. 753-760.
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abstract = "Background: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs). Objective: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile105Val genetic polymorphism on breast cancer risk. Design: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87{\%} of cases and 85{\%} of controls). Results: With the use of multivariate logistic regression, the GSTP1 Val/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95{\%} CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95{\%} CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95{\%} CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend < 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95{\%} CI: 1.13, 2.67) that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95{\%} CI = 1.20, 3.59). Conclusions: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.",
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T1 - Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk

AU - Lee, Sang Ah

AU - Fowke, Jay

AU - Lu, Wei

AU - Ye, Chuangzhong

AU - Zheng, Ying

AU - Cai, Qiuyin

AU - Gu, Kai

AU - Gao, Yu Tang

AU - Shu, Xiao Ou

AU - Zheng, Wei

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Background: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs). Objective: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile105Val genetic polymorphism on breast cancer risk. Design: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87% of cases and 85% of controls). Results: With the use of multivariate logistic regression, the GSTP1 Val/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95% CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95% CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95% CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend < 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95% CI: 1.13, 2.67) that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95% CI = 1.20, 3.59). Conclusions: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.

AB - Background: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs). Objective: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile105Val genetic polymorphism on breast cancer risk. Design: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87% of cases and 85% of controls). Results: With the use of multivariate logistic regression, the GSTP1 Val/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95% CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95% CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95% CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend < 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95% CI: 1.13, 2.67) that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95% CI = 1.20, 3.59). Conclusions: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.

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