Güneydoğu nijerya’daki enugu’da ortaokul Çocuklarında primer başağrısı

Prevalans, patern ve diğer karakteristikler

Translated title of the contribution: Curcumin improves chronic stress induced potentiated seizure activity in experimental model of epilepsy

Haydeh Haghighizad, Atefeh Touhidi, Ali Pourmotabbed, Farshad Moradpour, Seyed Ershad Nedaei, Tayebeh Pourmotabbed

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Curcuma longa is a traditional Chinese and Indian herbal medicine, which has been used to treat the symptoms of mental stress. As the major pigment in the rhizome of curcuma longa, curcumin has anti-oxidant, anti-inflammatory, and anti-convulsant activities. Exposure to the repetitive stress accelerates seizure activity in various model of epilepsy. Hence, we hypothesized that curcumin may ameliorate the effect of chronic stress on pentylenetetrazole (PTZ)-induced seizure activity in rats. Methods: We assessed whether chronic or acute curcumin treatment (20 mg/kg, i.p.) affects PTZ (60 mg/kg. i.p.)-induced seizure activity in a chronic restraint stress (14 days, 2 h/day) model in rats. The latency to, and the duration of myoclonic jerk rearing (stage 3) and generalized tonic-clonic seizures (GTCS), the latency to, and the number of myoclonic jerks as well as the maximum seizure severity score were observed for a 30 min period after PTZ injection. Results: We found that exposure to chronic stress prior to PTZ administration increased the duration of GTCS in animals, which could be reversed by chronic pre-administration of curcumin. In addition, curcumin pre-treatment alleviates the PTZ-induced seizure activity, increased the myoclonic jerks latency, decreased the duration of GTCS, and also decreased the severity of seizure as determined by seizure severity score. However, acute administration of curcumin (20 mg/kg, i.p.) 30 min before PTZ had no significant effect on the PTZ-induced seizure under stressful situation. Conclusion: Chronic but not acute curcumin is effective in management of seizure activity associated with daily stress in epileptic individuals.

Original languageTurkish
Pages (from-to)76-85
Number of pages10
JournalJournal of Neurological Sciences
Volume34
Issue number1
StatePublished - Jan 1 2017

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Curcumin
Epilepsy
Seizures
Theoretical Models
Pentylenetetrazole
Myoclonus
Curcuma
Convulsants
Rhizome
Herbal Medicine
Oxidants
Anti-Inflammatory Agents

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Güneydoğu nijerya’daki enugu’da ortaokul Çocuklarında primer başağrısı : Prevalans, patern ve diğer karakteristikler. / Haghighizad, Haydeh; Touhidi, Atefeh; Pourmotabbed, Ali; Moradpour, Farshad; Nedaei, Seyed Ershad; Pourmotabbed, Tayebeh.

In: Journal of Neurological Sciences, Vol. 34, No. 1, 01.01.2017, p. 76-85.

Research output: Contribution to journalArticle

Haghighizad, Haydeh ; Touhidi, Atefeh ; Pourmotabbed, Ali ; Moradpour, Farshad ; Nedaei, Seyed Ershad ; Pourmotabbed, Tayebeh. / Güneydoğu nijerya’daki enugu’da ortaokul Çocuklarında primer başağrısı : Prevalans, patern ve diğer karakteristikler. In: Journal of Neurological Sciences. 2017 ; Vol. 34, No. 1. pp. 76-85.
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abstract = "Objective: Curcuma longa is a traditional Chinese and Indian herbal medicine, which has been used to treat the symptoms of mental stress. As the major pigment in the rhizome of curcuma longa, curcumin has anti-oxidant, anti-inflammatory, and anti-convulsant activities. Exposure to the repetitive stress accelerates seizure activity in various model of epilepsy. Hence, we hypothesized that curcumin may ameliorate the effect of chronic stress on pentylenetetrazole (PTZ)-induced seizure activity in rats. Methods: We assessed whether chronic or acute curcumin treatment (20 mg/kg, i.p.) affects PTZ (60 mg/kg. i.p.)-induced seizure activity in a chronic restraint stress (14 days, 2 h/day) model in rats. The latency to, and the duration of myoclonic jerk rearing (stage 3) and generalized tonic-clonic seizures (GTCS), the latency to, and the number of myoclonic jerks as well as the maximum seizure severity score were observed for a 30 min period after PTZ injection. Results: We found that exposure to chronic stress prior to PTZ administration increased the duration of GTCS in animals, which could be reversed by chronic pre-administration of curcumin. In addition, curcumin pre-treatment alleviates the PTZ-induced seizure activity, increased the myoclonic jerks latency, decreased the duration of GTCS, and also decreased the severity of seizure as determined by seizure severity score. However, acute administration of curcumin (20 mg/kg, i.p.) 30 min before PTZ had no significant effect on the PTZ-induced seizure under stressful situation. Conclusion: Chronic but not acute curcumin is effective in management of seizure activity associated with daily stress in epileptic individuals.",
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T1 - Güneydoğu nijerya’daki enugu’da ortaokul Çocuklarında primer başağrısı

T2 - Prevalans, patern ve diğer karakteristikler

AU - Haghighizad, Haydeh

AU - Touhidi, Atefeh

AU - Pourmotabbed, Ali

AU - Moradpour, Farshad

AU - Nedaei, Seyed Ershad

AU - Pourmotabbed, Tayebeh

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N2 - Objective: Curcuma longa is a traditional Chinese and Indian herbal medicine, which has been used to treat the symptoms of mental stress. As the major pigment in the rhizome of curcuma longa, curcumin has anti-oxidant, anti-inflammatory, and anti-convulsant activities. Exposure to the repetitive stress accelerates seizure activity in various model of epilepsy. Hence, we hypothesized that curcumin may ameliorate the effect of chronic stress on pentylenetetrazole (PTZ)-induced seizure activity in rats. Methods: We assessed whether chronic or acute curcumin treatment (20 mg/kg, i.p.) affects PTZ (60 mg/kg. i.p.)-induced seizure activity in a chronic restraint stress (14 days, 2 h/day) model in rats. The latency to, and the duration of myoclonic jerk rearing (stage 3) and generalized tonic-clonic seizures (GTCS), the latency to, and the number of myoclonic jerks as well as the maximum seizure severity score were observed for a 30 min period after PTZ injection. Results: We found that exposure to chronic stress prior to PTZ administration increased the duration of GTCS in animals, which could be reversed by chronic pre-administration of curcumin. In addition, curcumin pre-treatment alleviates the PTZ-induced seizure activity, increased the myoclonic jerks latency, decreased the duration of GTCS, and also decreased the severity of seizure as determined by seizure severity score. However, acute administration of curcumin (20 mg/kg, i.p.) 30 min before PTZ had no significant effect on the PTZ-induced seizure under stressful situation. Conclusion: Chronic but not acute curcumin is effective in management of seizure activity associated with daily stress in epileptic individuals.

AB - Objective: Curcuma longa is a traditional Chinese and Indian herbal medicine, which has been used to treat the symptoms of mental stress. As the major pigment in the rhizome of curcuma longa, curcumin has anti-oxidant, anti-inflammatory, and anti-convulsant activities. Exposure to the repetitive stress accelerates seizure activity in various model of epilepsy. Hence, we hypothesized that curcumin may ameliorate the effect of chronic stress on pentylenetetrazole (PTZ)-induced seizure activity in rats. Methods: We assessed whether chronic or acute curcumin treatment (20 mg/kg, i.p.) affects PTZ (60 mg/kg. i.p.)-induced seizure activity in a chronic restraint stress (14 days, 2 h/day) model in rats. The latency to, and the duration of myoclonic jerk rearing (stage 3) and generalized tonic-clonic seizures (GTCS), the latency to, and the number of myoclonic jerks as well as the maximum seizure severity score were observed for a 30 min period after PTZ injection. Results: We found that exposure to chronic stress prior to PTZ administration increased the duration of GTCS in animals, which could be reversed by chronic pre-administration of curcumin. In addition, curcumin pre-treatment alleviates the PTZ-induced seizure activity, increased the myoclonic jerks latency, decreased the duration of GTCS, and also decreased the severity of seizure as determined by seizure severity score. However, acute administration of curcumin (20 mg/kg, i.p.) 30 min before PTZ had no significant effect on the PTZ-induced seizure under stressful situation. Conclusion: Chronic but not acute curcumin is effective in management of seizure activity associated with daily stress in epileptic individuals.

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