Curcumin Nanoformulation for Cervical Cancer Treatment

Mohd S. Zaman, Neeraj Chauhan, Murali Yallapu, Rishi K. Gara, Diane M. Maher, Sonam Kumari, Mohammed Sikander, Sheema Khan, Nadeem Zafar, Meena Jaggi, Subhash Chauhan

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Cervical cancer is one of the most common cancers among women worldwide. Current standards of care for cervical cancer includes surgery, radiation, and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses and causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be a highly viable option. Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins. However, due to rapid degradation and poor bioavailability, its translational and clinical use has been limited. To improve these clinically relevant parameters, we report a poly(lactic-co-glycolic acid) based curcumin nanoparticle formulation (Nano-CUR). This study demonstrates that in comparison to free CUR, Nano-CUR effectively inhibits cell growth, induces apoptosis, and arrests the cell cycle in cervical cancer cell lines. Nano-CUR treatment modulated entities such as miRNAs, transcription factors, and proteins associated with carcinogenesis. Moreover, Nano-CUR effectively reduced the tumor burden in a pre-clinical orthotopic mouse model of cervical cancer by decreasing oncogenic miRNA-21, suppressing nuclear β-catenin, and abrogating expression of E6/E7 HPV oncoproteins including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression. These superior pre-clinical data suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.

Original languageEnglish (US)
Article number20051
JournalScientific Reports
Volume6
DOIs
StatePublished - Feb 3 2016

Fingerprint

Curcumin
Uterine Cervical Neoplasms
Therapeutics
MicroRNAs
Drug Therapy
Catenins
Benzo(a)pyrene
Oncogene Proteins
Standard of Care
Cell Cycle Checkpoints
Tumor Burden
Biological Products
Nanoparticles
Biological Availability
Interleukin-6
Neoplasms
Carcinogenesis
Proteins
Transcription Factors
Smoking

All Science Journal Classification (ASJC) codes

  • General

Cite this

Curcumin Nanoformulation for Cervical Cancer Treatment. / Zaman, Mohd S.; Chauhan, Neeraj; Yallapu, Murali; Gara, Rishi K.; Maher, Diane M.; Kumari, Sonam; Sikander, Mohammed; Khan, Sheema; Zafar, Nadeem; Jaggi, Meena; Chauhan, Subhash.

In: Scientific Reports, Vol. 6, 20051, 03.02.2016.

Research output: Contribution to journalArticle

Zaman, MS, Chauhan, N, Yallapu, M, Gara, RK, Maher, DM, Kumari, S, Sikander, M, Khan, S, Zafar, N, Jaggi, M & Chauhan, S 2016, 'Curcumin Nanoformulation for Cervical Cancer Treatment', Scientific Reports, vol. 6, 20051. https://doi.org/10.1038/srep20051
Zaman MS, Chauhan N, Yallapu M, Gara RK, Maher DM, Kumari S et al. Curcumin Nanoformulation for Cervical Cancer Treatment. Scientific Reports. 2016 Feb 3;6. 20051. https://doi.org/10.1038/srep20051
Zaman, Mohd S. ; Chauhan, Neeraj ; Yallapu, Murali ; Gara, Rishi K. ; Maher, Diane M. ; Kumari, Sonam ; Sikander, Mohammed ; Khan, Sheema ; Zafar, Nadeem ; Jaggi, Meena ; Chauhan, Subhash. / Curcumin Nanoformulation for Cervical Cancer Treatment. In: Scientific Reports. 2016 ; Vol. 6.
@article{77bc558d7b6b4aca91743146edeb1a27,
title = "Curcumin Nanoformulation for Cervical Cancer Treatment",
abstract = "Cervical cancer is one of the most common cancers among women worldwide. Current standards of care for cervical cancer includes surgery, radiation, and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses and causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be a highly viable option. Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins. However, due to rapid degradation and poor bioavailability, its translational and clinical use has been limited. To improve these clinically relevant parameters, we report a poly(lactic-co-glycolic acid) based curcumin nanoparticle formulation (Nano-CUR). This study demonstrates that in comparison to free CUR, Nano-CUR effectively inhibits cell growth, induces apoptosis, and arrests the cell cycle in cervical cancer cell lines. Nano-CUR treatment modulated entities such as miRNAs, transcription factors, and proteins associated with carcinogenesis. Moreover, Nano-CUR effectively reduced the tumor burden in a pre-clinical orthotopic mouse model of cervical cancer by decreasing oncogenic miRNA-21, suppressing nuclear β-catenin, and abrogating expression of E6/E7 HPV oncoproteins including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression. These superior pre-clinical data suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.",
author = "Zaman, {Mohd S.} and Neeraj Chauhan and Murali Yallapu and Gara, {Rishi K.} and Maher, {Diane M.} and Sonam Kumari and Mohammed Sikander and Sheema Khan and Nadeem Zafar and Meena Jaggi and Subhash Chauhan",
year = "2016",
month = "2",
day = "3",
doi = "10.1038/srep20051",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Curcumin Nanoformulation for Cervical Cancer Treatment

AU - Zaman, Mohd S.

AU - Chauhan, Neeraj

AU - Yallapu, Murali

AU - Gara, Rishi K.

AU - Maher, Diane M.

AU - Kumari, Sonam

AU - Sikander, Mohammed

AU - Khan, Sheema

AU - Zafar, Nadeem

AU - Jaggi, Meena

AU - Chauhan, Subhash

PY - 2016/2/3

Y1 - 2016/2/3

N2 - Cervical cancer is one of the most common cancers among women worldwide. Current standards of care for cervical cancer includes surgery, radiation, and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses and causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be a highly viable option. Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins. However, due to rapid degradation and poor bioavailability, its translational and clinical use has been limited. To improve these clinically relevant parameters, we report a poly(lactic-co-glycolic acid) based curcumin nanoparticle formulation (Nano-CUR). This study demonstrates that in comparison to free CUR, Nano-CUR effectively inhibits cell growth, induces apoptosis, and arrests the cell cycle in cervical cancer cell lines. Nano-CUR treatment modulated entities such as miRNAs, transcription factors, and proteins associated with carcinogenesis. Moreover, Nano-CUR effectively reduced the tumor burden in a pre-clinical orthotopic mouse model of cervical cancer by decreasing oncogenic miRNA-21, suppressing nuclear β-catenin, and abrogating expression of E6/E7 HPV oncoproteins including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression. These superior pre-clinical data suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.

AB - Cervical cancer is one of the most common cancers among women worldwide. Current standards of care for cervical cancer includes surgery, radiation, and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses and causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be a highly viable option. Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins. However, due to rapid degradation and poor bioavailability, its translational and clinical use has been limited. To improve these clinically relevant parameters, we report a poly(lactic-co-glycolic acid) based curcumin nanoparticle formulation (Nano-CUR). This study demonstrates that in comparison to free CUR, Nano-CUR effectively inhibits cell growth, induces apoptosis, and arrests the cell cycle in cervical cancer cell lines. Nano-CUR treatment modulated entities such as miRNAs, transcription factors, and proteins associated with carcinogenesis. Moreover, Nano-CUR effectively reduced the tumor burden in a pre-clinical orthotopic mouse model of cervical cancer by decreasing oncogenic miRNA-21, suppressing nuclear β-catenin, and abrogating expression of E6/E7 HPV oncoproteins including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression. These superior pre-clinical data suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.

UR - http://www.scopus.com/inward/record.url?scp=84957818730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957818730&partnerID=8YFLogxK

U2 - 10.1038/srep20051

DO - 10.1038/srep20051

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 20051

ER -