Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis

Souvik Banerjee, Dong Jin Hwang, Wei Li, Duane Miller

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties.

Original languageEnglish (US)
Article number1468
JournalMolecules
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Tubulin Modulators
angiogenesis
Drug delivery
Nanoparticles
inhibitors
Blood Vessels
delivery
drugs
Tumors
nanoparticles
tumors
Microtubules
Pharmaceutical Preparations
Blood vessels
Cytotoxicity
blood vessels
Neoplasms
Excipients
disrupting
Tumor Cell Line

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis. / Banerjee, Souvik; Hwang, Dong Jin; Li, Wei; Miller, Duane.

In: Molecules, Vol. 21, No. 11, 1468, 01.11.2016.

Research output: Contribution to journalReview article

@article{0f5b59c68ec744c4b069eaee67372eb5,
title = "Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis",
abstract = "Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties.",
author = "Souvik Banerjee and Hwang, {Dong Jin} and Wei Li and Duane Miller",
year = "2016",
month = "11",
day = "1",
doi = "10.3390/molecules21111468",
language = "English (US)",
volume = "21",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

TY - JOUR

T1 - Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis

AU - Banerjee, Souvik

AU - Hwang, Dong Jin

AU - Li, Wei

AU - Miller, Duane

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties.

AB - Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties.

UR - http://www.scopus.com/inward/record.url?scp=84994059918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994059918&partnerID=8YFLogxK

U2 - 10.3390/molecules21111468

DO - 10.3390/molecules21111468

M3 - Review article

VL - 21

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 11

M1 - 1468

ER -