Current concepts in long QT syndrome

H. Li, J. Fuentes-Garcia, Jeffrey Towbin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Sudden cardiac death occurs in the United States with an incidence of more than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In young persons in whom no structural heart disease can be identified, the long QT syndromes (LQTS) are commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all of which encode cardiac ion channels. These include two potassium channel α subunits (KVLQTl and HERG), two potassium channel β subunits (minK and MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes, particularly in young patients.

Original languageEnglish (US)
Pages (from-to)542-550
Number of pages9
JournalPediatric Cardiology
Volume21
Issue number6
DOIs
StatePublished - Nov 13 2000
Externally publishedYes

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Long QT Syndrome
Potassium Channels
Mink
Sodium Channels
Sudden Cardiac Death
Ion Channels
Genes
Cardiac Arrhythmias
Molecular Biology
Cause of Death
Heart Diseases
Phenotype
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Current concepts in long QT syndrome. / Li, H.; Fuentes-Garcia, J.; Towbin, Jeffrey.

In: Pediatric Cardiology, Vol. 21, No. 6, 13.11.2000, p. 542-550.

Research output: Contribution to journalArticle

Li, H. ; Fuentes-Garcia, J. ; Towbin, Jeffrey. / Current concepts in long QT syndrome. In: Pediatric Cardiology. 2000 ; Vol. 21, No. 6. pp. 542-550.
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