Current management of recurrent ependymoma

Frederick Boop, Jody Helms, Thomas E. Merchant

Research output: Contribution to journalArticle

Abstract

Ependymoma is the third most common type of nervous system neoplasm found in the pediatric population. Children with ependymoma, and especially the young child, have historically had a poor prognosis. Many studies have sought to improve cure and survival rates among these children. Four important themes have emerged; extent of resection, histology of the tumor, age at presentation, and adjuvant chemoradiation. From these themes, the best strategy for initial management has become gross total resection followed by postoperative radiation therapy. Higher grade and very young age have been a negative prognostic indicator. Despite the success chemotherapy has shown in other types of tumors, it is not be found overly useful in the treatment of ependymoma. However, even with improved outcomes, recurrences still frequently occur both locally and metastatic. When feasible, local re-resection, metastatic resection, and re-irradiation have shown promise as salvage therapy, with chemotherapy again having disappointing results. Until new, novel approaches to ependymoma treatment are developed, these strategies appear to be the best therapeutic approaches to date.

Original languageEnglish (US)
Pages (from-to)134-140
Number of pages7
JournalPan Arab Journal of Neurosurgery
Volume12
Issue numberSPEC. ISS.
StatePublished - 2008

Fingerprint

Ependymoma
Nervous System Neoplasms
Drug Therapy
Salvage Therapy
Neoplasms
Histology
Radiotherapy
Therapeutics
Pediatrics
Recurrence
Population

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Boop, F., Helms, J., & Merchant, T. E. (2008). Current management of recurrent ependymoma. Pan Arab Journal of Neurosurgery, 12(SPEC. ISS.), 134-140.

Current management of recurrent ependymoma. / Boop, Frederick; Helms, Jody; Merchant, Thomas E.

In: Pan Arab Journal of Neurosurgery, Vol. 12, No. SPEC. ISS., 2008, p. 134-140.

Research output: Contribution to journalArticle

Boop, F, Helms, J & Merchant, TE 2008, 'Current management of recurrent ependymoma', Pan Arab Journal of Neurosurgery, vol. 12, no. SPEC. ISS., pp. 134-140.
Boop F, Helms J, Merchant TE. Current management of recurrent ependymoma. Pan Arab Journal of Neurosurgery. 2008;12(SPEC. ISS.):134-140.
Boop, Frederick ; Helms, Jody ; Merchant, Thomas E. / Current management of recurrent ependymoma. In: Pan Arab Journal of Neurosurgery. 2008 ; Vol. 12, No. SPEC. ISS. pp. 134-140.
@article{aa780900f2f14db7bbaad3347b9b5ca7,
title = "Current management of recurrent ependymoma",
abstract = "Ependymoma is the third most common type of nervous system neoplasm found in the pediatric population. Children with ependymoma, and especially the young child, have historically had a poor prognosis. Many studies have sought to improve cure and survival rates among these children. Four important themes have emerged; extent of resection, histology of the tumor, age at presentation, and adjuvant chemoradiation. From these themes, the best strategy for initial management has become gross total resection followed by postoperative radiation therapy. Higher grade and very young age have been a negative prognostic indicator. Despite the success chemotherapy has shown in other types of tumors, it is not be found overly useful in the treatment of ependymoma. However, even with improved outcomes, recurrences still frequently occur both locally and metastatic. When feasible, local re-resection, metastatic resection, and re-irradiation have shown promise as salvage therapy, with chemotherapy again having disappointing results. Until new, novel approaches to ependymoma treatment are developed, these strategies appear to be the best therapeutic approaches to date.",
author = "Frederick Boop and Jody Helms and Merchant, {Thomas E.}",
year = "2008",
language = "English (US)",
volume = "12",
pages = "134--140",
journal = "Pan Arab Journal of Neurosurgery",
issn = "1319-6995",
publisher = "Pan Arab Neurosurgical Society",
number = "SPEC. ISS.",

}

TY - JOUR

T1 - Current management of recurrent ependymoma

AU - Boop, Frederick

AU - Helms, Jody

AU - Merchant, Thomas E.

PY - 2008

Y1 - 2008

N2 - Ependymoma is the third most common type of nervous system neoplasm found in the pediatric population. Children with ependymoma, and especially the young child, have historically had a poor prognosis. Many studies have sought to improve cure and survival rates among these children. Four important themes have emerged; extent of resection, histology of the tumor, age at presentation, and adjuvant chemoradiation. From these themes, the best strategy for initial management has become gross total resection followed by postoperative radiation therapy. Higher grade and very young age have been a negative prognostic indicator. Despite the success chemotherapy has shown in other types of tumors, it is not be found overly useful in the treatment of ependymoma. However, even with improved outcomes, recurrences still frequently occur both locally and metastatic. When feasible, local re-resection, metastatic resection, and re-irradiation have shown promise as salvage therapy, with chemotherapy again having disappointing results. Until new, novel approaches to ependymoma treatment are developed, these strategies appear to be the best therapeutic approaches to date.

AB - Ependymoma is the third most common type of nervous system neoplasm found in the pediatric population. Children with ependymoma, and especially the young child, have historically had a poor prognosis. Many studies have sought to improve cure and survival rates among these children. Four important themes have emerged; extent of resection, histology of the tumor, age at presentation, and adjuvant chemoradiation. From these themes, the best strategy for initial management has become gross total resection followed by postoperative radiation therapy. Higher grade and very young age have been a negative prognostic indicator. Despite the success chemotherapy has shown in other types of tumors, it is not be found overly useful in the treatment of ependymoma. However, even with improved outcomes, recurrences still frequently occur both locally and metastatic. When feasible, local re-resection, metastatic resection, and re-irradiation have shown promise as salvage therapy, with chemotherapy again having disappointing results. Until new, novel approaches to ependymoma treatment are developed, these strategies appear to be the best therapeutic approaches to date.

UR - http://www.scopus.com/inward/record.url?scp=57749107447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57749107447&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 134

EP - 140

JO - Pan Arab Journal of Neurosurgery

JF - Pan Arab Journal of Neurosurgery

SN - 1319-6995

IS - SPEC. ISS.

ER -