Current trends in the molecular classification of renal neoplasms.

Andrew N. Young, Viraj A. Master, Mahul Amin

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. However, light microscopic diagnosis of RCC subtypes is often difficult due to variable histology. In addition, the clinical behavior of RCC is highly variable and therapeutic response rates are poor. Few clinical assays are available to predict outcome in RCC or correlate behavior with histology. Therefore, novel RCC classification systems based on gene expression should be useful for diagnosis, prognosis, and treatment. Recent microarray studies have shown that renal tumors are characterized by distinct gene expression profiles, which can be used to discover novel diagnostic and prognostic biomarkers. Here, we review clinical features of kidney cancer, the WHO classification system, and the growing role of molecular classification for diagnosis, prognosis, and therapy of this disease.

Original languageEnglish (US)
Pages (from-to)2505-2518
Number of pages14
JournalTheScientificWorldJournal
Volume6
DOIs
StatePublished - Jan 1 2006

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Kidney Neoplasms
Renal Cell Carcinoma
histology
World Health Organization
Histology
tumor
gene expression
cancer
Gene expression
Tumors
Cells
Health
biomarker
Light
microscopy
Biomarkers
mutation
Microarrays
Optical microscopy
assay

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Current trends in the molecular classification of renal neoplasms. / Young, Andrew N.; Master, Viraj A.; Amin, Mahul.

In: TheScientificWorldJournal, Vol. 6, 01.01.2006, p. 2505-2518.

Research output: Contribution to journalReview article

Young, Andrew N. ; Master, Viraj A. ; Amin, Mahul. / Current trends in the molecular classification of renal neoplasms. In: TheScientificWorldJournal. 2006 ; Vol. 6. pp. 2505-2518.
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