Current understanding of klotho

Yuhong Wang, Zhongjie Sun

Research output: Contribution to journalShort survey

162 Citations (Scopus)

Abstract

Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. Klotho functions as a cofactor/coreceptor regulating fibroblast growth factor (FGF) 23 signaling. Klotho acts as a glucuronidase and activates ion channel TRPV5. Klotho protects against endothelial dysfunction and regulates the production of nitric oxide. Klotho also influences intracellular signaling pathways including p53/p21, cAMP, protein kinase C (PKC) and Wnt signaling pathways. The discovery of klotho has a great impact on aging research. The purpose of this review is to provide the recent progress and future directions of klotho research. Specifically, this review will cover: klotho and aging, structure and expression of the klotho gene, localization of klotho expression, source of circulating klotho, current understanding of klotho functions, and signaling pathways of klotho.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalAgeing Research Reviews
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Aging of materials
Premature Aging
Wnt Signaling Pathway
Glucuronidase
Ion Channels
Research
Oxidants
Protein Kinase C
Genes
Nitric Oxide
Insulin
Phenotype
Gene Expression
Mutation
Direction compound
fibroblast growth factor 23

All Science Journal Classification (ASJC) codes

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Current understanding of klotho. / Wang, Yuhong; Sun, Zhongjie.

In: Ageing Research Reviews, Vol. 8, No. 1, 01.01.2009, p. 43-51.

Research output: Contribution to journalShort survey

Wang, Yuhong ; Sun, Zhongjie. / Current understanding of klotho. In: Ageing Research Reviews. 2009 ; Vol. 8, No. 1. pp. 43-51.
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