Cutaneous leiomyosarcoma

Treatment and outcomes with a standardized margin of resection

Jeremiah Deneve, Jane L. Messina, Marilyn M. Bui, Suroosh S. Marzban, G. Douglas Letson, David Cheong, Ricardo J. Gonzalez, Vernon K. Sondak, Jonathan S. Zager

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Cutaneous leiomyosarcoma is primarily a low-grade malignancy that affects elderly male Caucasians. It is a rare dermal-based tumor for which treatment algorithms have been poorly defined. Methods: We retrospectively reviewed the use of a median 1-cm margin for resection to treat patients with cutaneous leiomyosarcoma referred for treatment between 2005 and 2010. Results: Thirty-three patients with cutaneous leiomyosarcoma were treated. Of these, 76% were male, 97% were Caucasian (median age: 63.5 years), and 67% of tumors were located on the extremities. Preoperative staging was negative for distant metastasis in all patients. A majority of the tumors (88%) were low grade (median size: 1.3 cm). All of the tumors were positive for smooth-muscle actin. A total of 94% of patients underwent primary surgical resection with a median margin of 1 cm. Final resection margin was negative in 97% of patients. Adjuvant radiotherapy was used in 15%. No metastatic spread or recurrences were present, and 100% of patients were alive at last follow-up (median: 15.5 months). Conclusions: Good oncological control and excellent outcomes are possible with a 1-cm resection margin in most cases of cutaneous leiomyosarcoma.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalCancer Control
Volume20
Issue number4
DOIs
StatePublished - Jan 1 2013

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Leiomyosarcoma
Skin
Neoplasms
Adjuvant Radiotherapy
Smooth Muscle
Margins of Excision
Actins
Extremities
Neoplasm Metastasis
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Deneve, J., Messina, J. L., Bui, M. M., Marzban, S. S., Letson, G. D., Cheong, D., ... Zager, J. S. (2013). Cutaneous leiomyosarcoma: Treatment and outcomes with a standardized margin of resection. Cancer Control, 20(4), 307-312. https://doi.org/10.1177/107327481302000408

Cutaneous leiomyosarcoma : Treatment and outcomes with a standardized margin of resection. / Deneve, Jeremiah; Messina, Jane L.; Bui, Marilyn M.; Marzban, Suroosh S.; Letson, G. Douglas; Cheong, David; Gonzalez, Ricardo J.; Sondak, Vernon K.; Zager, Jonathan S.

In: Cancer Control, Vol. 20, No. 4, 01.01.2013, p. 307-312.

Research output: Contribution to journalArticle

Deneve, J, Messina, JL, Bui, MM, Marzban, SS, Letson, GD, Cheong, D, Gonzalez, RJ, Sondak, VK & Zager, JS 2013, 'Cutaneous leiomyosarcoma: Treatment and outcomes with a standardized margin of resection', Cancer Control, vol. 20, no. 4, pp. 307-312. https://doi.org/10.1177/107327481302000408
Deneve, Jeremiah ; Messina, Jane L. ; Bui, Marilyn M. ; Marzban, Suroosh S. ; Letson, G. Douglas ; Cheong, David ; Gonzalez, Ricardo J. ; Sondak, Vernon K. ; Zager, Jonathan S. / Cutaneous leiomyosarcoma : Treatment and outcomes with a standardized margin of resection. In: Cancer Control. 2013 ; Vol. 20, No. 4. pp. 307-312.
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