Cutting edge

A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway

Karim C. El Kasmi, Amber Smith, Lynn Williams, Geoffrey Neale, Athanasia Panopolous, Stephanie S. Watowich, Hans Häcker, Brian M.J. Foxwell, Peter J. Murray

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on proinflammatory mediator production. In this study we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3, and a helicase family corepressor, Strawberry notch homologue 2 (SBNO2), in mouse and human macrophages. IL-10-mediated induction of ETV3 and SBNO2 expression was dependent upon both STAT3 and a stimulus through the TLR pathway. We also observed that ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway. ETV3 and SBNO2 repressed NF-κB- but not IFN regulatory factor 7 (IRF7)-activated transcriptional reporters. Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10.

Original languageEnglish (US)
Pages (from-to)7215-7219
Number of pages5
JournalJournal of Immunology
Volume179
Issue number11
DOIs
StatePublished - Dec 1 2007

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Co-Repressor Proteins
Interleukin-10
Anti-Inflammatory Agents
Fragaria
Interleukin-6
Macrophages
Gene Expression

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Cutting edge : A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. / El Kasmi, Karim C.; Smith, Amber; Williams, Lynn; Neale, Geoffrey; Panopolous, Athanasia; Watowich, Stephanie S.; Häcker, Hans; Foxwell, Brian M.J.; Murray, Peter J.

In: Journal of Immunology, Vol. 179, No. 11, 01.12.2007, p. 7215-7219.

Research output: Contribution to journalArticle

El Kasmi, KC, Smith, A, Williams, L, Neale, G, Panopolous, A, Watowich, SS, Häcker, H, Foxwell, BMJ & Murray, PJ 2007, 'Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway', Journal of Immunology, vol. 179, no. 11, pp. 7215-7219. https://doi.org/10.4049/jimmunol.179.11.7215
El Kasmi, Karim C. ; Smith, Amber ; Williams, Lynn ; Neale, Geoffrey ; Panopolous, Athanasia ; Watowich, Stephanie S. ; Häcker, Hans ; Foxwell, Brian M.J. ; Murray, Peter J. / Cutting edge : A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. In: Journal of Immunology. 2007 ; Vol. 179, No. 11. pp. 7215-7219.
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