Cyclic alternating chemotherapy for small cell carcinoma of the lung

N. Murray, A. Shah, K. Wilson, J. Goldie, N. Voss, C. Fryer, Paul Klimo, P. Coy, E. Hadzic, G. Gudauskas

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Eighty-two previously untreated patients with small cell cancer of the lung were treated with six cycles of two alternating drug regimens: a new combination of mitomycin, methotrexate, and etoposide; and cyclophosphamide, doxorubicin, and vincristine. No maintenance chemotherapy was used. Consolidative thoracic irradiation and prophylactic cranial irradiation were employed. The median survival time for 32 limited-disease patients was 59 weeks, and for 50 extensive-disease patients was 35 weeks. Four-year survival was 12% for limited-disease patients and 2% for extensive-disease patients. These results were not superior to conventional combination chemotherapy regimens.

Original languageEnglish (US)
Pages (from-to)1241-1242
Number of pages2
JournalCancer Treatment Reports
Volume69
Issue number11
StatePublished - Dec 1 1985
Externally publishedYes

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Small Cell Lung Carcinoma
Drug Therapy
Maintenance Chemotherapy
Cranial Irradiation
Survival
Mitomycin
Vincristine
Etoposide
Combination Drug Therapy
Methotrexate
Doxorubicin
Cyclophosphamide
Thorax
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Murray, N., Shah, A., Wilson, K., Goldie, J., Voss, N., Fryer, C., ... Gudauskas, G. (1985). Cyclic alternating chemotherapy for small cell carcinoma of the lung. Cancer Treatment Reports, 69(11), 1241-1242.

Cyclic alternating chemotherapy for small cell carcinoma of the lung. / Murray, N.; Shah, A.; Wilson, K.; Goldie, J.; Voss, N.; Fryer, C.; Klimo, Paul; Coy, P.; Hadzic, E.; Gudauskas, G.

In: Cancer Treatment Reports, Vol. 69, No. 11, 01.12.1985, p. 1241-1242.

Research output: Contribution to journalArticle

Murray, N, Shah, A, Wilson, K, Goldie, J, Voss, N, Fryer, C, Klimo, P, Coy, P, Hadzic, E & Gudauskas, G 1985, 'Cyclic alternating chemotherapy for small cell carcinoma of the lung', Cancer Treatment Reports, vol. 69, no. 11, pp. 1241-1242.
Murray N, Shah A, Wilson K, Goldie J, Voss N, Fryer C et al. Cyclic alternating chemotherapy for small cell carcinoma of the lung. Cancer Treatment Reports. 1985 Dec 1;69(11):1241-1242.
Murray, N. ; Shah, A. ; Wilson, K. ; Goldie, J. ; Voss, N. ; Fryer, C. ; Klimo, Paul ; Coy, P. ; Hadzic, E. ; Gudauskas, G. / Cyclic alternating chemotherapy for small cell carcinoma of the lung. In: Cancer Treatment Reports. 1985 ; Vol. 69, No. 11. pp. 1241-1242.
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AU - Klimo, Paul

AU - Coy, P.

AU - Hadzic, E.

AU - Gudauskas, G.

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N2 - Eighty-two previously untreated patients with small cell cancer of the lung were treated with six cycles of two alternating drug regimens: a new combination of mitomycin, methotrexate, and etoposide; and cyclophosphamide, doxorubicin, and vincristine. No maintenance chemotherapy was used. Consolidative thoracic irradiation and prophylactic cranial irradiation were employed. The median survival time for 32 limited-disease patients was 59 weeks, and for 50 extensive-disease patients was 35 weeks. Four-year survival was 12% for limited-disease patients and 2% for extensive-disease patients. These results were not superior to conventional combination chemotherapy regimens.

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