Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children

Mary Ellen Hoehn, Steven R. Kelly, Matthew Wilson, R. Christopher Walton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of conventional therapy. After 6 months, dry eye manifestations improved in three children (27.3%). The remaining eight children showed no improvement with cyclosporine 0.05% ophthalmic emulsion. These results suggest that twice-daily cyclosporine 0.05% ophthalmic emulsion has limited use in children with refractory radiation-associated chronic dry eye.

Original languageEnglish (US)
JournalPediatric Blood and Cancer
Volume60
Issue number7
DOIs
StatePublished - Jul 1 2013

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Emulsions
Cyclosporine
Radiation
Eye Manifestations
Therapeutics
Eye Diseases
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. / Hoehn, Mary Ellen; Kelly, Steven R.; Wilson, Matthew; Walton, R. Christopher.

In: Pediatric Blood and Cancer, Vol. 60, No. 7, 01.07.2013.

Research output: Contribution to journalArticle

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