CYLD

A DUB with Many Talents

Sara J.S. Simonson, Zhaohui Wu, Shigeki Miyamoto

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

The deubiquitinating enzyme CYLD is a tumor suppressor protein known for its role in repression of generally pro-oncogenic NF-κB activation pathways. Two new studies published in this and the September issue of Developmental Cell show that CYLD dismantles distinct types of polyubiquitin chains formed on select signaling proteins and is thereby required for normal vertebrate and invertebrate development.

Original languageEnglish (US)
Pages (from-to)601-603
Number of pages3
JournalDevelopmental Cell
Volume13
Issue number5
DOIs
StatePublished - Nov 6 2007
Externally publishedYes

Fingerprint

Polyubiquitin
Tumor Suppressor Proteins
Aptitude
Invertebrates
Vertebrates
Chemical activation
Enzymes
Proteins
Deubiquitinating Enzymes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

CYLD : A DUB with Many Talents. / Simonson, Sara J.S.; Wu, Zhaohui; Miyamoto, Shigeki.

In: Developmental Cell, Vol. 13, No. 5, 06.11.2007, p. 601-603.

Research output: Contribution to journalShort survey

Simonson, SJS, Wu, Z & Miyamoto, S 2007, 'CYLD: A DUB with Many Talents', Developmental Cell, vol. 13, no. 5, pp. 601-603. https://doi.org/10.1016/j.devcel.2007.10.009
Simonson, Sara J.S. ; Wu, Zhaohui ; Miyamoto, Shigeki. / CYLD : A DUB with Many Talents. In: Developmental Cell. 2007 ; Vol. 13, No. 5. pp. 601-603.
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