Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids

Santosh Kumar, P. S.S. Rao, Namita Sinha, Narasimha M. Midde

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Substance abuse, especially alcohol drinking and tobacco smoking, is highly prevalent in the HIV-infected population. HIV medication using antiretroviral therapy (ART) has led to an increase in the life span of HIV patients. The increased life span of HIV-positive patients, concurrent with increased use of alcohol and tobacco, has resulted in the development of neuroAIDS. In the past few years there has been increasing interest in investigating the interactions among alcohol, tobacco, HIV, and ART to achieve better treatment strategies for HIV-infected alcohol drinkers and tobacco smokers. Among other hypotheses, the involvement of cytochrome P450 (CYP) and oxidative stress pathways leading to exacerbated neuroAIDS has received much attention. This chapter covers the impact of alcohol and tobacco on neuroAIDS and advancements in the understanding of the involvement of CYP and oxidative stress pathways in alcohol- and tobacco-mediated neuroAIDS.

Original languageEnglish (US)
Title of host publicationFoundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
PublisherElsevier Inc.
Pages179-188
Number of pages10
Volume1
ISBN (Electronic)9780128003763
ISBN (Print)9780128002131
DOIs
StatePublished - Mar 23 2016

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Cytochrome P-450 Enzyme System
Tobacco
Oxidative Stress
Alcohols
HIV
Tobacco Use
Alcohol Drinking
Substance-Related Disorders
Neuroaid
Therapeutics
Smoking
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kumar, S., Rao, P. S. S., Sinha, N., & Midde, N. M. (2016). Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids (Vol. 1, pp. 179-188). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800213-1.00017-1

Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids. / Kumar, Santosh; Rao, P. S.S.; Sinha, Namita; Midde, Narasimha M.

Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. p. 179-188.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kumar, S, Rao, PSS, Sinha, N & Midde, NM 2016, Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids. in Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. vol. 1, Elsevier Inc., pp. 179-188. https://doi.org/10.1016/B978-0-12-800213-1.00017-1
Kumar S, Rao PSS, Sinha N, Midde NM. Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1. Elsevier Inc. 2016. p. 179-188 https://doi.org/10.1016/B978-0-12-800213-1.00017-1
Kumar, Santosh ; Rao, P. S.S. ; Sinha, Namita ; Midde, Narasimha M. / Cytochrome p450 and oxidative stress as possible pathways for alcohol- and tobacco-mediated hiv pathogenesis and neuroaids. Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. pp. 179-188
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