Cytology and flow cytometry to identify ectopic thymic tissue masquerading as a thyroid nodule in two children

Lourdes Aguayo-Figueroa, Marc G. Golightly, Youjun Hu, Harris Cohen, Thomas A. Wilson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Clinically unapparent thyroid nodules in children pose a significant problem in differential diagnosis and management. Ectopic thymic tissue in the thyroid gland is rare, but may masquerade as a thyroid nodule. This paper demonstrates the utility of flow cytometry as an adjunct to cytology by fine needle aspiration in diagnosing ectopic thymic tissue in the thyroid gland. Summary: By demonstration of T lymphocytes maturing along two cell lineages and the absence of markers for malignant lesions, fine-needle aspiration, cytology, and flow cytometry were used to identify ectopic thymic tissue masquerading as a thyroid nodule in two children. Conclusion: Use of this technique prevented surgical intervention that otherwise would have been necessary to obtain an accurate diagnosis of these thyroid nodules.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalThyroid
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

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Choristoma
Thyroid Nodule
Cell Biology
Flow Cytometry
Fine Needle Biopsy
Thyroid Gland
Cell Lineage
Differential Diagnosis
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Cytology and flow cytometry to identify ectopic thymic tissue masquerading as a thyroid nodule in two children. / Aguayo-Figueroa, Lourdes; Golightly, Marc G.; Hu, Youjun; Cohen, Harris; Wilson, Thomas A.

In: Thyroid, Vol. 19, No. 4, 01.04.2009, p. 403-406.

Research output: Contribution to journalArticle

Aguayo-Figueroa, Lourdes ; Golightly, Marc G. ; Hu, Youjun ; Cohen, Harris ; Wilson, Thomas A. / Cytology and flow cytometry to identify ectopic thymic tissue masquerading as a thyroid nodule in two children. In: Thyroid. 2009 ; Vol. 19, No. 4. pp. 403-406.
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