Cytotoxic antibodies in preoperative glioma patients

A diagnostic assay

J. P. Phillips, M. Sujatanond, R. L. Martuza, E. A. Quindlen, W. C. Wood, P. L. Kornblith, F Dohan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The use of a microcytotoxicity test for complement-dependent serum antibodies cytotoxic to cultured astrocytoma cells has been explored as an aid in the diagnosis of brain tumors. Fourteen of 21 randomly selected preoperative glioma patients (67%) had antibodies detectable by this assay in contrast to 4 of 21 normal blood donors (19%). Five of the glioma patients (24%) were strongly positive (cytotoxic index > 80 · 80) while none of the controls was in this range. Although positive responses were seen in patients with tumors of every grade, only 6 of 11 patients with astrocytomas of Grades I-III were positive as compared to 8 of 9 patients with Grade IV astrocytomas. The microcytotoxicity test used is simple, inexpensive and capable of being performed on an outpatient basis. It is concluded that this assay has usefulness both as a screening technique and as a diagnostic adjunct for patients suspected of having brain tumors.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalActa Neurochirurgica
Volume35
Issue number1-3
DOIs
StatePublished - Mar 1 1976
Externally publishedYes

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Glioma
Antibodies
Immunologic Cytotoxicity Tests
Astrocytoma
Brain Neoplasms
Glioblastoma
Blood Donors
Cultured Cells
Outpatients
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Phillips, J. P., Sujatanond, M., Martuza, R. L., Quindlen, E. A., Wood, W. C., Kornblith, P. L., & Dohan, F. (1976). Cytotoxic antibodies in preoperative glioma patients: A diagnostic assay. Acta Neurochirurgica, 35(1-3), 43-52. https://doi.org/10.1007/BF01405931

Cytotoxic antibodies in preoperative glioma patients : A diagnostic assay. / Phillips, J. P.; Sujatanond, M.; Martuza, R. L.; Quindlen, E. A.; Wood, W. C.; Kornblith, P. L.; Dohan, F.

In: Acta Neurochirurgica, Vol. 35, No. 1-3, 01.03.1976, p. 43-52.

Research output: Contribution to journalArticle

Phillips, JP, Sujatanond, M, Martuza, RL, Quindlen, EA, Wood, WC, Kornblith, PL & Dohan, F 1976, 'Cytotoxic antibodies in preoperative glioma patients: A diagnostic assay', Acta Neurochirurgica, vol. 35, no. 1-3, pp. 43-52. https://doi.org/10.1007/BF01405931
Phillips JP, Sujatanond M, Martuza RL, Quindlen EA, Wood WC, Kornblith PL et al. Cytotoxic antibodies in preoperative glioma patients: A diagnostic assay. Acta Neurochirurgica. 1976 Mar 1;35(1-3):43-52. https://doi.org/10.1007/BF01405931
Phillips, J. P. ; Sujatanond, M. ; Martuza, R. L. ; Quindlen, E. A. ; Wood, W. C. ; Kornblith, P. L. ; Dohan, F. / Cytotoxic antibodies in preoperative glioma patients : A diagnostic assay. In: Acta Neurochirurgica. 1976 ; Vol. 35, No. 1-3. pp. 43-52.
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