Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women

Bo Qin, Patricia G. Moorman, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Joellen M. Schildkraut, Elisa V. Bandera

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. Methods: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049). Conclusions: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.

Original languageEnglish (US)
Pages (from-to)1122-1130
Number of pages9
JournalBritish Journal of Cancer
Volume115
Issue number9
DOIs
StatePublished - Oct 25 2016

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Vitamin D
African Americans
Ovarian Neoplasms
Odds Ratio
Calcium
Lactose
Confidence Intervals
Solar System
Logistic Models
Vitamin D Deficiency
Dairy Products
Case-Control Studies
Milk
Epidemiology
Diet
Mortality
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Qin, B., Moorman, P. G., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., Cote, M. L., ... Bandera, E. V. (2016). Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women. British Journal of Cancer, 115(9), 1122-1130. https://doi.org/10.1038/bjc.2016.289

Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women. / Qin, Bo; Moorman, Patricia G.; Alberg, Anthony J.; Barnholtz-Sloan, Jill S.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Schildkraut, Joellen M.; Bandera, Elisa V.

In: British Journal of Cancer, Vol. 115, No. 9, 25.10.2016, p. 1122-1130.

Research output: Contribution to journalArticle

Qin, B, Moorman, PG, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Terry, P, Schildkraut, JM & Bandera, EV 2016, 'Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women', British Journal of Cancer, vol. 115, no. 9, pp. 1122-1130. https://doi.org/10.1038/bjc.2016.289
Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML et al. Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women. British Journal of Cancer. 2016 Oct 25;115(9):1122-1130. https://doi.org/10.1038/bjc.2016.289
Qin, Bo ; Moorman, Patricia G. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Schildkraut, Joellen M. ; Bandera, Elisa V. / Dairy, calcium, Vitamin D and ovarian cancer risk in African-American women. In: British Journal of Cancer. 2016 ; Vol. 115, No. 9. pp. 1122-1130.
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abstract = "Background: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. Methods: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95{\%} confidence intervals (CIs). Results: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95{\%} CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI{\%}: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95{\%} CI: 0.51-0.99; P-trend: 0.049). Conclusions: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.",
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