Decrease in sweet taste in rats after gastric bypass surgery

David S. Tichansky, A. Rebecca Glatt, Atul K. Madan, Jason Harper, Kenichi Tokita, John Boughter

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: The literature contains evidence that Roux-en-Y gastric bypass (RYGB) surgery has an effect in humans on taste and preference for carbohydrate-rich foods. This study tested the hypothesis that RYGB affects sweet taste behavior using a rat model. Methods: Male Sprague-Dawley rats underwent either RYGB or sham surgery. Then 4 weeks after surgery, the rats were given taste-salient, brief-access lick tests with a series of sucrose concentrations. Results: The RYGB rats, but not the sham rats, lost weight over the 5-week postoperative period. The RYGB rats showed a significant decrease in mean licks for the highest concentration of sucrose (0.25-1.0 mol/l) but not for the low concentrations of sucrose or water. Conclusions: The findings showed that RYGB surgery affected sweet taste behavior in rats, with postsurgical rats having lower sensitivity or avidity for sucrose than sham-treated control rats. This finding is similar to human reports that sweet taste and preferences for high-caloric foods are altered after bypass surgery.

Original languageEnglish (US)
Pages (from-to)1176-1181
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2011

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Gastric Bypass
Sucrose
Food
Postoperative Period
Sprague Dawley Rats
Carbohydrates
Weights and Measures
Water

All Science Journal Classification (ASJC) codes

  • Surgery

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Decrease in sweet taste in rats after gastric bypass surgery. / Tichansky, David S.; Rebecca Glatt, A.; Madan, Atul K.; Harper, Jason; Tokita, Kenichi; Boughter, John.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 25, No. 4, 01.04.2011, p. 1176-1181.

Research output: Contribution to journalArticle

Tichansky, David S. ; Rebecca Glatt, A. ; Madan, Atul K. ; Harper, Jason ; Tokita, Kenichi ; Boughter, John. / Decrease in sweet taste in rats after gastric bypass surgery. In: Surgical Endoscopy and Other Interventional Techniques. 2011 ; Vol. 25, No. 4. pp. 1176-1181.
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