Decreased dynorphin a (1-17) in the spinal cord of spastic rats after the compressive injury

Hongwei Dong, Li Hua Wang, Min Zhang, Ji Sheng Han

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Spasticity in rat hindlimbs was induced by compressing cervical spinal cord with a wax ball. Ashworth score and H-reflex were measured 1 week after the surgery. The results showed that: (1) muscle spasm was detected in the hindlimbs a week after the operation and maintained at least 8 weeks, (2) in the spastic animals, dynorphin A (1-17)-ir decreased significantly in thoracic and lumbar segments of the spinal cord and (3) peripheral administration of κ receptor agonist U50488H and electrical stimulation at 100 Hz effectively relieved the muscle spasm. Our data supported the note that the reduction of endogenous dynorphin A (1-17) might play an important role in the pathogenesis of spinally induced muscle spasticity and the replenishment of its shortage might relieve the spasticity.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalBrain Research Bulletin
Volume67
Issue number3
DOIs
StatePublished - Oct 15 2005

Fingerprint

Dynorphins
Muscle Spasticity
Spasm
Hindlimb
Spinal Cord
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
H-Reflex
Waxes
Wounds and Injuries
Electric Stimulation
Thorax
Cervical Cord

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Decreased dynorphin a (1-17) in the spinal cord of spastic rats after the compressive injury. / Dong, Hongwei; Wang, Li Hua; Zhang, Min; Han, Ji Sheng.

In: Brain Research Bulletin, Vol. 67, No. 3, 15.10.2005, p. 189-195.

Research output: Contribution to journalArticle

Dong, Hongwei ; Wang, Li Hua ; Zhang, Min ; Han, Ji Sheng. / Decreased dynorphin a (1-17) in the spinal cord of spastic rats after the compressive injury. In: Brain Research Bulletin. 2005 ; Vol. 67, No. 3. pp. 189-195.
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