Decreased GABA receptor binding in the cerebral cortex of insulin induced hypoglycemic and streptozotocin induced diabetic rats

Sherin Antony, T. Peeyush Kumar, Korah Pushpamangalam Kuruvilla, Naijil George, C. S. Paulose

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including seizures, coma and death. GABAergic inhibitory function in the cerebral cortex plays an important role in controlling the excitability and responsiveness of cortical neurons. Present study analysed effects of insulin induced hypoglycemia and streptozotocin induced diabetes on the cortical GABA receptor binding, GABAAá1, GABAB receptor subtype expression, GAD and GLUT3 expression. Diabetic rats showed decreased [3H] GABA binding in the cerebral cortex compared to control while hypoglycemia exacerbated the decrease. GABA receptor subunits; GABAAá1, GABAB and GAD expression significantly decreased in diabetic rats whereas hypoglycemia significanly decreased the expression compared to diabetic. GLUT3 expression significantly up regulated during both hypo and hyperglycemia. Our results showed that hypoglycemia and hyperglycemia decreased GABAergic neuroprotective function in the cerebral cortex, which account for the increased vulnerability of cerebral cortex to subsequent neuronal damage during hypo/hyperglycemia.

Original languageEnglish (US)
Pages (from-to)1516-1521
Number of pages6
JournalNeurochemical Research
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2010

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GABA Receptors
Streptozocin
Medical problems
Hypoglycemia
Hypoglycemic Agents
Cerebral Cortex
Rats
Insulin
Hyperglycemia
gamma-Aminobutyric Acid
Neurons
Blood Glucose
Experimental Diabetes Mellitus
Coma
Seizures
Homeostasis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Decreased GABA receptor binding in the cerebral cortex of insulin induced hypoglycemic and streptozotocin induced diabetic rats. / Antony, Sherin; Peeyush Kumar, T.; Pushpamangalam Kuruvilla, Korah; George, Naijil; Paulose, C. S.

In: Neurochemical Research, Vol. 35, No. 10, 01.10.2010, p. 1516-1521.

Research output: Contribution to journalArticle

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