Decreased habituation of midlatency auditory evoked responses in Parkinson's disease

Charles Teo, Lisa Rasco, Kynda Al-Mefty, Robert D. Skinner, Frederick Boop, Edgar Garcia-Rill

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Abstract

The P1 midlatency auditory evoked potential was studied in patients with Parkinson's disease and compared to that in age-matched controls. Habituation of the potential was determined by using a two-click stimulus paradigm in which the stimuli were presented at 250-, 500-, and 1000-ms interstimulus intervals. Results showed that habituation of the P1 potential had a statistically significant decrease at the 250-ms and 500-ms interstimulus intervals in patients with Parkinson's disease compared to normal controls. The degree of decreased habituation was found to increase with severity of the disease such that stage 5 patients showed greater decreases in habituation compared to stage 4, as did stage 4 compared to stage 3. These findings may be explained by the presence of a dysregulation of sensory processing, possibly by elements of the reticular activating system, including the pedunculopontine nucleus, in Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)655-664
Number of pages10
JournalMovement Disorders
Volume12
Issue number5
DOIs
StatePublished - Oct 7 1997

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Auditory Evoked Potentials
Parkinson Disease

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Decreased habituation of midlatency auditory evoked responses in Parkinson's disease. / Teo, Charles; Rasco, Lisa; Al-Mefty, Kynda; Skinner, Robert D.; Boop, Frederick; Garcia-Rill, Edgar.

In: Movement Disorders, Vol. 12, No. 5, 07.10.1997, p. 655-664.

Research output: Contribution to journalArticle

Teo, C, Rasco, L, Al-Mefty, K, Skinner, RD, Boop, F & Garcia-Rill, E 1997, 'Decreased habituation of midlatency auditory evoked responses in Parkinson's disease', Movement Disorders, vol. 12, no. 5, pp. 655-664. https://doi.org/10.1002/mds.870120506
Teo, Charles ; Rasco, Lisa ; Al-Mefty, Kynda ; Skinner, Robert D. ; Boop, Frederick ; Garcia-Rill, Edgar. / Decreased habituation of midlatency auditory evoked responses in Parkinson's disease. In: Movement Disorders. 1997 ; Vol. 12, No. 5. pp. 655-664.
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