Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice

Kristen A. Mehl, J. Mark Davis, Julie M. Clements, Franklin G. Berger, Maria M. Pena, James Carson

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Moderate-intensity treadmill running can alter male ApcMin/+ mouse polyp formation. This purpose of this study was to examine whether exercise mode differentially affects ApcMin/+ mouse intestinal polyp development in male and female mice. Male and female ApcMin/+ mice were randomly assigned to control, treadmill (18 m/min; 60 min/day; 6 days/wk), or voluntary wheel running (24-h access) groups. Nine weeks of training decreased total intestinal polyps by 29% in male treadmill runners (66 ± 9; P = 0.038) compared with male controls (93 ± 7). The number of large polyps (≥1-mm diameter) were also reduced by 38% in male treadmill runners (49 ± 6; P = 0.005) compared with male controls (79 ± 6). Treadmill running in female ApcMin/+ mice and wheel running in both genders did not affect polyp number or size. Spleen weight decreased in male treadmill runners (91 ± 9 mg; P = 0.011) and wheel runners (75 ± 6 mg; P = 0.004) compared with controls (141 ± 13 mg). Plasma IL-6 was reduced by 96% in male treadmill runners (1.2 ± 0.6 pg/ml) and 78% in male wheel runners (6.6 ± 3.3 pg/ml) compared with control mice (27.9 ± 2.8 pg/ml; P < 0.05). Female mice responded similarly with an 86% decrease in plasma IL-6 with treadmill running (3.2 ± 1.2 pg/ml) and 90% decrease with wheel running (2.9 ± 2.0 pg/ml) compared with control mice (21.1 ± 5.3 pg/ml; P < 0.05). The crypt depth-to-villus height ratio in the intestine, an indirect marker of intestinal inflammation, decreased by 21 (P = 0.024) and 24% (P = 0.029), respectively, in male and female treadmill runners but not wheel runners. Physical activity-induced attenuation of intestinal polyp number and size is dependent on exercise mode and differs between genders. The modulation of systemic and intestinal inflammation may also depend on exercise mode.

Original languageEnglish (US)
Pages (from-to)2219-2225
Number of pages7
JournalJournal of Applied Physiology
Volume98
Issue number6
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

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Intestinal Polyps
Running
Polyps
Interleukin-6
Inflammation
Intestines

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. / Mehl, Kristen A.; Davis, J. Mark; Clements, Julie M.; Berger, Franklin G.; Pena, Maria M.; Carson, James.

In: Journal of Applied Physiology, Vol. 98, No. 6, 01.06.2005, p. 2219-2225.

Research output: Contribution to journalArticle

Mehl, Kristen A. ; Davis, J. Mark ; Clements, Julie M. ; Berger, Franklin G. ; Pena, Maria M. ; Carson, James. / Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. In: Journal of Applied Physiology. 2005 ; Vol. 98, No. 6. pp. 2219-2225.
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