Defective expression of high affinity IL-2 receptors on activated T cells from aged humans

Risë Schwab, Lawrence Pfeffer, Paul Szabo, David Gamble, Christine M. Schnurr, Marc E. Weksler

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The proliferative response of T cells from aged humans to a number of mitogens is significantly reduced. We report here that there is a decrease in high affinity IL-2 receptor (IL-2R) expression on activated T cells from aged humans. Scatchard analysis of the binding of [125l]IL-2 demonstrates fewer high affinity IL-2 binding sites. Autoradiographic techniques demonstrate that this results from there being fewer activated T cells from old as compared to young donors that express high affinity IL-2R. However, T cells from old donors that do not express high affinity IL-2 binding sites express both the IL-2 binding 55 and 75 kd chains. Thus, although the two IL-2 binding peptldes are expressed on activated T cells from old donors, expression of the high affinity IL-2R Is reduced. This may explain the decreased ability of T cells from old donors to respond to IL-2. The impaired ability of activated T cells from old donors to express high affinity IL-2R while expressing the 55 and 75 kd chains may provide insights Into the mechanisms of IL-2 Interactions with its receptor.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalInternational Immunology
Volume2
Issue number3
DOIs
StatePublished - Mar 1 1990

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Interleukin-2 Receptors
Interleukin-2
T-Lymphocytes
Binding Sites
Mitogens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Defective expression of high affinity IL-2 receptors on activated T cells from aged humans. / Schwab, Risë; Pfeffer, Lawrence; Szabo, Paul; Gamble, David; Schnurr, Christine M.; Weksler, Marc E.

In: International Immunology, Vol. 2, No. 3, 01.03.1990, p. 239-246.

Research output: Contribution to journalArticle

Schwab, Risë ; Pfeffer, Lawrence ; Szabo, Paul ; Gamble, David ; Schnurr, Christine M. ; Weksler, Marc E. / Defective expression of high affinity IL-2 receptors on activated T cells from aged humans. In: International Immunology. 1990 ; Vol. 2, No. 3. pp. 239-246.
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