Defibrillation causes immediate cardiac dilation in humans

Erin Sylvester, Brent Hoffmeister, Eric Johnson, Paul Hess, Robert Malkin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Prior studies in isolated heart tissue have shown both excitation and deexcitation to be the primary mechanism of defibrillation. This article presents the first evidence in man of deexcitation immediately following defibrillation by tracking the heart's mechanical response. Methods and Results: The geometric changes of the ventricular chambers were measured before and after defibrillation in seven human subjects receiving an implantable cardioverter defibrillator (ICD). The ICD was used to produce approximately three episodes of ventricular fibrillation and defibrillation in each subject. Twenty-two two-dimensional echocardiographic images of the right ventricle (RV) and 11 images of the left ventricle (LV) were recorded and analyzed at 30 frames per second. Just over 2 seconds of each episode were digitized, beginning half a second before the defibrillation shock. Individual frames were analyzed to yield cross-sectional, ventricular chamber area as a function of time. Immediately following defibrillation, ventricular chambers dilated with significant fractional area increase (RV: 1.58 ± 0.25, LV: 1.10 ± 0.06), with peak dilation at 194 ± 114 msec. Conclusion: Defibrillation causes a rapid increase in ventricular chamber area due to relaxation of the myocardium, suggesting that defibrillation synchronizes the cardiac cells to the deexcited state in man.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalJournal of cardiovascular electrophysiology
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2003

Fingerprint

Heart Ventricles
Dilatation
Implantable Defibrillators
Ventricular Fibrillation
Shock
Myocardium

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Defibrillation causes immediate cardiac dilation in humans. / Sylvester, Erin; Hoffmeister, Brent; Johnson, Eric; Hess, Paul; Malkin, Robert.

In: Journal of cardiovascular electrophysiology, Vol. 14, No. 8, 01.08.2003, p. 832-836.

Research output: Contribution to journalArticle

Sylvester, Erin ; Hoffmeister, Brent ; Johnson, Eric ; Hess, Paul ; Malkin, Robert. / Defibrillation causes immediate cardiac dilation in humans. In: Journal of cardiovascular electrophysiology. 2003 ; Vol. 14, No. 8. pp. 832-836.
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