Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables

A new weapon to blunt prostate cancer growth

Bilal Hafeez, Mohammad Asim, Imtiaz Ahmad Siddiqui, Vaqar Mustafa Adhami, Imtiyaz Murtaza, Hasan Mukhtar

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

In a recent publication, we have shown that delphinidin, an anthocyanidin induces apoptosis and cell cycle arrest in highly metastatic human prostate cancer (PCa) PC3 cells. Extending these studies, we provide additional evidence that delphinidin induces apoptosis and cell cycle arrest in androgen refractory human PCa 22Rν1 cells and that these effects are concomitant with inhibition of NFκB. We observed that delphinidin treatment to 22Rν1 cells resulted in a dose-dependent (i) G2/M phase cell cycle arrest, (ii) induction of apoptosis (iii) and inhibition of NFκB signaling. The induction of apoptosis by delphinidin was mediated via activation of caspases since a general caspase inhibitor Z-VAD-FMK significantly reversed this effect. Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKγ (NEMO), (ii) phosphorylation of NFκB inhibitory protein IκBα, (iii) phosphorylation of NFκB/p65 at Ser536 and NFκB/p50 at Ser529, (iv) NFκB/p65 nuclear translocation, and (v) NFκB DNA binding activity. Taken together, our data show that delphinidin induces apoptosis of both androgen independent and androgen refractory human PCa cells via activation of caspases and in addition, this effect might be due to inhibition of NFκB signaling. We suggest that delphinidin could be developed as a novel agent against PCa.

Original languageEnglish (US)
Pages (from-to)3320-3326
Number of pages7
JournalCell Cycle
Volume7
Issue number21
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

delphinidin
Weapons
Anthocyanins
Vegetables
Fruit
Prostatic Neoplasms
Growth
Apoptosis
Androgens
Phosphorylation
Caspases
Cell Cycle Checkpoints
M Phase Cell Cycle Checkpoints
Caspase Inhibitors
G2 Phase

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Hafeez, B., Asim, M., Siddiqui, I. A., Adhami, V. M., Murtaza, I., & Mukhtar, H. (2008). Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: A new weapon to blunt prostate cancer growth. Cell Cycle, 7(21), 3320-3326.

Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables : A new weapon to blunt prostate cancer growth. / Hafeez, Bilal; Asim, Mohammad; Siddiqui, Imtiaz Ahmad; Adhami, Vaqar Mustafa; Murtaza, Imtiyaz; Mukhtar, Hasan.

In: Cell Cycle, Vol. 7, No. 21, 01.11.2008, p. 3320-3326.

Research output: Contribution to journalReview article

Hafeez, B, Asim, M, Siddiqui, IA, Adhami, VM, Murtaza, I & Mukhtar, H 2008, 'Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: A new weapon to blunt prostate cancer growth', Cell Cycle, vol. 7, no. 21, pp. 3320-3326.
Hafeez, Bilal ; Asim, Mohammad ; Siddiqui, Imtiaz Ahmad ; Adhami, Vaqar Mustafa ; Murtaza, Imtiyaz ; Mukhtar, Hasan. / Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables : A new weapon to blunt prostate cancer growth. In: Cell Cycle. 2008 ; Vol. 7, No. 21. pp. 3320-3326.
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