Demonstration of an activation regulated NF-κB/I-κBα complex in human platelets

Fengqi Liu, Steve A. Morris, Jerry Epps, Roger C. Carroll

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

In eukaryotic cells, the ubiquity of the signaling system of transcription factor nuclear factor-kappa B (NF-κB)/I-kappa B (I-κB) is undisputed. Numerous studies have reported that the NF-κB/I-κB complex plays a pivotal role in regulating gene expression controlling cell differentiation, cell proliferation, inflammation, oncogenesis, and apoptosis. Here we show that NF-κB/I-κB families exist in human platelets, natural anuclear corpuscles derived from megakaryocytes. Moreover, the I-κB kinase (IKK) is present and may phosphorylate I-κB during platelet activation. Coupled with intracellular calcium flux, this leads to I-κB dissociation from the NF-κB/I-κB complex and proteolysis. The NF-κB/I-κB proteins may have function independent of gene regulation in platelets.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalThrombosis Research
Volume106
Issue number4-5
DOIs
StatePublished - May 15 2002

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NF-kappa B
Blood Platelets
I-kappa B Proteins
Megakaryocytes
Platelet Activation
Eukaryotic Cells
Proteolysis
Cell Differentiation
Carcinogenesis
Transcription Factors
Phosphotransferases
Cell Proliferation
Apoptosis
Inflammation
Calcium
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Demonstration of an activation regulated NF-κB/I-κBα complex in human platelets. / Liu, Fengqi; Morris, Steve A.; Epps, Jerry; Carroll, Roger C.

In: Thrombosis Research, Vol. 106, No. 4-5, 15.05.2002, p. 199-203.

Research output: Contribution to journalArticle

Liu, Fengqi ; Morris, Steve A. ; Epps, Jerry ; Carroll, Roger C. / Demonstration of an activation regulated NF-κB/I-κBα complex in human platelets. In: Thrombosis Research. 2002 ; Vol. 106, No. 4-5. pp. 199-203.
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