Dental pulp and dentin tissue engineering and regeneration: Advancement and challenge

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Hard tissue is difficult to repair especially dental structures. Tooth enamel is incapable of self-repairing whereas dentin and cememtum can regenerate with limited capacity. Enamel and dentin are commonly under the attack by caries. Extensive forms of caries destroy enamel and dentin and can lead to dental pulp infection. Entire pulp amputation followed by the pulp space disinfection and filled with an artificial rubber-like material is employed to treat the infection - commonly known as root canal or endodontic therapy. Regeneration of dentin relies on having vital pulps; however, regeneration of pulp tissue has been difficult as the tissue is encased in dentin without collateral blood supply except from the root apical end. With the advent of modern tissue engineering concept and the discovery of dental stem cells, regeneration of pulp and dentin has been tested. This article will review the recent endeavor on pulp and dentin tissue engineering and regeneration. The prospective outcome of the current advancement and challenge in this line of research will be discussed.

Original languageEnglish (US)
Pages (from-to)788-800
Number of pages13
JournalFrontiers in Bioscience - Elite
Volume3 E
Issue number2
StatePublished - Jan 1 2011

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Dental Pulp
Tissue regeneration
Dentin
Tissue Engineering
Tissue engineering
Pulp
Regeneration
Dental Enamel
Tooth
Enamels
Tissue
Tooth enamel
Disinfection
Dental Pulp Cavity
Endodontics
Rubber
Canals
Infection
Stem cells
Amputation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Dental pulp and dentin tissue engineering and regeneration : Advancement and challenge. / Huang, George.

In: Frontiers in Bioscience - Elite, Vol. 3 E, No. 2, 01.01.2011, p. 788-800.

Research output: Contribution to journalArticle

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