Desensitization of human platelets by platelet activating factor

Carolyn M. Chesney, D. David Pifer, Kim Huch

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Human platelets are less responsive to PAF at 37° than at 25°. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alteration of a metabolic step subsequent to binding cannot be excluded, but platelets show normal response to a variety of other agents under the conditions resulting in desensitization of platelets to PAF.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume127
Issue number1
DOIs
StatePublished - Feb 28 1985

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Platelet Activating Factor
Platelets
Blood Platelets
Binding Sites

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Desensitization of human platelets by platelet activating factor. / Chesney, Carolyn M.; Pifer, D. David; Huch, Kim.

In: Biochemical and Biophysical Research Communications, Vol. 127, No. 1, 28.02.1985, p. 24-30.

Research output: Contribution to journalArticle

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