Design and engineering of nanogels for cancer treatment

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Here, we provide a comprehensive insight into current advances in the use of nanogel-mediated chemotherapy for cancer treatment. Nanogels are composed of cross-linked three-dimensional polymer chain networks that are formed via covalent linkages or self-assembly processes. The porosity between the cross-linked networks of nanogels not only provides an ideal reservoir for loading drugs, oligonucleotides and imaging agents, but also protects them from environmental degradation and hazards. Here, we focus mainly on novel synthetic strategies and key considerations in the design of nanogel-based drug delivery systems for controlled and targeted cancer therapeutic applications.

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalDrug Discovery Today
Volume16
Issue number9-10
DOIs
StatePublished - May 1 2011
Externally publishedYes

Fingerprint

Neoplasms
Porosity
Therapeutics
Drug Delivery Systems
Oligonucleotides
Polymers
Drug Therapy
NanoGel
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology

Cite this

Design and engineering of nanogels for cancer treatment. / Yallapu, Murali; Jaggi, Meena; Chauhan, Subhash.

In: Drug Discovery Today, Vol. 16, No. 9-10, 01.05.2011, p. 457-463.

Research output: Contribution to journalReview article

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