Design and performance of a new SPECT detector for multimodality small animal imaging platforms

Derek W. Austin, Michael J. Paulus, Shaun S. Gleason, Robert A. Mintzer, Stefan B. Siegel, Said D. Figueroa, Timothy J. Hoffman, Jonathan Wall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Citations (Scopus)

Abstract

A new detector for single photon emission computed tomography (SPECT) has been developed for the Siemens microCAT® II and Inveon Multimodality preclinical imaging systems. The detector provides an active imaging area of 15 cm × 15 cm. We review the design of this new SPECT detector and present some key performance characteristics. Integral and differential uniformity were 3.7% and 3.0%, respectively. Mean energy resolution for 99mTc (140 keV) was 12.5%. Sensitivity as high as 1400 cps/MBq was measured for 99mTc on a dual-detector system, and a spatial resolution of 0.7 mm (FWHM) was obtained using 0.5 mm single pinhole collimators. Additionally, we present data from representative preclinical SPECT studies acquired with single and multi-pinhole collimators and multiple isotopes. Reconstructed images demonstrate that this detector is capable of high-resolution SPECT for multimodality small animal imaging.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3008-3011
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - Jan 1 2006
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

Fingerprint

Single-Photon Emission-Computed Tomography
animals
platforms
tomography
detectors
photons
pinholes
collimators
Isotopes
isotopes
spatial resolution
sensitivity
high resolution
energy

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Austin, D. W., Paulus, M. J., Gleason, S. S., Mintzer, R. A., Siegel, S. B., Figueroa, S. D., ... Wall, J. (2006). Design and performance of a new SPECT detector for multimodality small animal imaging platforms. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 3008-3011). [4179665] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.356508

Design and performance of a new SPECT detector for multimodality small animal imaging platforms. / Austin, Derek W.; Paulus, Michael J.; Gleason, Shaun S.; Mintzer, Robert A.; Siegel, Stefan B.; Figueroa, Said D.; Hoffman, Timothy J.; Wall, Jonathan.

2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc., 2006. p. 3008-3011 4179665 (IEEE Nuclear Science Symposium Conference Record; Vol. 5).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Austin, DW, Paulus, MJ, Gleason, SS, Mintzer, RA, Siegel, SB, Figueroa, SD, Hoffman, TJ & Wall, J 2006, Design and performance of a new SPECT detector for multimodality small animal imaging platforms. in 2006 IEEE Nuclear Science Symposium - Conference Record., 4179665, IEEE Nuclear Science Symposium Conference Record, vol. 5, Institute of Electrical and Electronics Engineers Inc., pp. 3008-3011, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 10/29/06. https://doi.org/10.1109/NSSMIC.2006.356508
Austin DW, Paulus MJ, Gleason SS, Mintzer RA, Siegel SB, Figueroa SD et al. Design and performance of a new SPECT detector for multimodality small animal imaging platforms. In 2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc. 2006. p. 3008-3011. 4179665. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2006.356508
Austin, Derek W. ; Paulus, Michael J. ; Gleason, Shaun S. ; Mintzer, Robert A. ; Siegel, Stefan B. ; Figueroa, Said D. ; Hoffman, Timothy J. ; Wall, Jonathan. / Design and performance of a new SPECT detector for multimodality small animal imaging platforms. 2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc., 2006. pp. 3008-3011 (IEEE Nuclear Science Symposium Conference Record).
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