Design of an Integrated Sensor for in Vivo Simultaneous Electrocontractile Cardiac Mapping

Benjamin A. Schnitz, Dongxu Guan, Robert A. Malkin

Research output: Contribution to journalArticle

Abstract

While there is extensive mapping of the spread of electrical activity in the heart, there have been no measurements of electrical and localized mechanical, or contractile, activity. Yet the development of effective treatments for diseases like chronic heart failure and cardiac hypertrophy depend on the ability to quantify improvements in electrocontractile function. In this paper, we present a sensor that is capable of making simultaneous, electro-contractile measurements. Its small size facilitates placement in multiple myocardial sites for multichannel studies. Semiconductor strain gages are used for force sensing, and Ag/AgCl-plated tungsten electrodes act as electrogram sensors. The sensor contains electronics on-board, including instrumentation amplifiers and a microprocessor for data sampling and analog-to-digital conversion. Each sensor can accurately detect 0-245±5 mV in two electrogram channels with a sensitivity of 0.96±0.2 mV/step and less than 2% error, and 0-144±29 g of contractile force with a sensitivity of 0.56±0.11 g/step in the analog-to-digital conversion and less than 6% error. The sensor has been tested in vivo in open-chest rabbit and pig mapping studies. These studies indicated that the average peak-to-peak contractile force at the apex is smaller in the rabbit than the pig (13.3 versus 40.3 g), that the average peak-to-peak contractile force in the pig is smaller near the base than near the apex (31.3 versus 40.3 g), and that contractile force is visibly decreased during ventricular fibrillation compared to normal sinus rhythm.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2004

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Sensors
Analog to digital conversion
Strain gages
Printed circuit boards
Tungsten
Microprocessor chips
Electronic equipment
Semiconductor materials
Sampling
Electrodes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Design of an Integrated Sensor for in Vivo Simultaneous Electrocontractile Cardiac Mapping. / Schnitz, Benjamin A.; Guan, Dongxu; Malkin, Robert A.

In: IEEE Transactions on Biomedical Engineering, Vol. 51, No. 2, 01.02.2004, p. 355-361.

Research output: Contribution to journalArticle

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