Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging

Wenbin Zeng, Weimin Miao, Michael Le Puil, Guangqing Shi, John Biggerstaff, George Kabalka, David Townsend

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Apoptosis (programmed cell death) plays a crucial role in the pathogenesis of many disorders, thus the detection of apoptotic cells can provide the physician with important information to further therapeutic strategies and would substantially advance patient care. A small molecule, 4-(5-dimethylamino-naphthalene-1-sulfonamido)-3-(4-iodo-phenyl)butanoic acid (DNSBA), was designed as a novel probe for imaging apoptosis and synthesized with good yield. The biological characterization demonstrated that DNSBA can be used to specifically and selectively detect apoptotic cancer cells at all stages. DNSBA is also designed as a potential SPECT and PET probe when labeled with radioiodine (I-123, -124, and -131).

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume398
Issue number3
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

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Molecular Probes
Butyric Acid
Cells
Apoptosis
Imaging techniques
Cell death
Single-Photon Emission-Computed Tomography
Patient Care
Cell Death
Physicians
Molecules
Neoplasms
naphthalene
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging. / Zeng, Wenbin; Miao, Weimin; Le Puil, Michael; Shi, Guangqing; Biggerstaff, John; Kabalka, George; Townsend, David.

In: Biochemical and Biophysical Research Communications, Vol. 398, No. 3, 01.07.2010, p. 571-575.

Research output: Contribution to journalArticle

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AU - Kabalka, George

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