Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis

Wenbin Zeng, Weimin Miao, George Kabalka, Michael Le Puil, John Biggerstaff, David Townsend

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.

Original languageEnglish (US)
Pages (from-to)6429-6432
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number45
DOIs
StatePublished - Nov 3 2008
Externally publishedYes

Fingerprint

Annexin A5
Biomarkers
Cell membranes
Cells
Apoptosis
Derivatives
Imaging techniques
Amino Acids
Molecules
Cytoplasm
Cell Membrane
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis. / Zeng, Wenbin; Miao, Weimin; Kabalka, George; Puil, Michael Le; Biggerstaff, John; Townsend, David.

In: Tetrahedron Letters, Vol. 49, No. 45, 03.11.2008, p. 6429-6432.

Research output: Contribution to journalArticle

Zeng, Wenbin ; Miao, Weimin ; Kabalka, George ; Puil, Michael Le ; Biggerstaff, John ; Townsend, David. / Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 45. pp. 6429-6432.
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