Destruction of the inferior colliculus disrupts the production and inhibition of fear conditioned to an acoustic stimulus

Scott Heldt, William A. Falls

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The inferior colliculus (IC) is the major source of auditory information involved in processing the behavioral significance of acoustic stimuli. In the current study, we assessed whether the IC is a critical source of information which mediates the expression of fear and the inhibition of fear conditioned to an auditory stimulus. Fear and the inhibition of fear were tested by measuring fear-potentiated startle. In Experiment 1, we demonstrated that rats which received electrolytic lesions of the IC failed to show fear-potentiated startle in the presence of a noise previously conditioned to elicit fear. In Experiment 2, we demonstrated that rats with similarly placed lesions of the IC failed to inhibit fear-potentiated startle in the presence of a noise previously conditioned to inhibit fear to a light. Thus, in both Experiments 1 and 2, lesions of the IC disrupted the behavioral significance of the noise stimulus. Together with previous findings, these results are consistent with the view that the IC is a common source of diverging auditory information used to mediate the fear eliciting and safety signal properties conditioned to auditory stimuli.

Original languageEnglish (US)
Pages (from-to)175-185
Number of pages11
JournalBehavioural Brain Research
Volume144
Issue number1-2
DOIs
StatePublished - Sep 15 2003

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Inferior Colliculi
Acoustics
Fear
Noise
Inhibition (Psychology)
Safety
Light

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Destruction of the inferior colliculus disrupts the production and inhibition of fear conditioned to an acoustic stimulus. / Heldt, Scott; Falls, William A.

In: Behavioural Brain Research, Vol. 144, No. 1-2, 15.09.2003, p. 175-185.

Research output: Contribution to journalArticle

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