Detection of a rabbit uteroglobin-like protein in human neonatal tracheobronchial washings

Ramasubbareddy Dhanireddy, Tadahiro Kikukawa, Anil B. Mukherjee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Uteroglobin is a steroid hormone dependent, low molecular weight, secretory protein with many immunomodulatory properties. Immunomodulation by this protein may, at least in part, be related to its inhibitory effects on phospholipase A2 activity. Although uteroglobin is conclusively found in the rabbit, its presence in the human is controversial. Here, we present biochemical and immunological evidence for the detection of a uteroglobin-like protein in the wet epithelial living of the respiratory tract of human neonates. Because inhibition of phospholipase A2 may modulate tissue eicosanoid levels and since many eicosanoids (i.e. prostaglandins and leukotrienes etc.) are well known regulators of smooth muscle contractility, cellular migration and inflammatory processes, the discovery of this protein in the human respiratory tract may have important physiological implications.

Original languageEnglish (US)
Pages (from-to)1447-1454
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume152
Issue number3
DOIs
StatePublished - May 16 1988
Externally publishedYes

Fingerprint

Uteroglobin
Washing
Rabbits
Eicosanoids
Phospholipases A2
Respiratory System
Proteins
Steroid hormones
Immunomodulation
Leukotrienes
Prostaglandins
Smooth Muscle
Muscle
Molecular Weight
Molecular weight
Steroids
Hormones
Tissue

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Detection of a rabbit uteroglobin-like protein in human neonatal tracheobronchial washings. / Dhanireddy, Ramasubbareddy; Kikukawa, Tadahiro; Mukherjee, Anil B.

In: Biochemical and Biophysical Research Communications, Vol. 152, No. 3, 16.05.1988, p. 1447-1454.

Research output: Contribution to journalArticle

@article{1c11ce88babd43cfa2cd23a1aa38cd33,
title = "Detection of a rabbit uteroglobin-like protein in human neonatal tracheobronchial washings",
abstract = "Uteroglobin is a steroid hormone dependent, low molecular weight, secretory protein with many immunomodulatory properties. Immunomodulation by this protein may, at least in part, be related to its inhibitory effects on phospholipase A2 activity. Although uteroglobin is conclusively found in the rabbit, its presence in the human is controversial. Here, we present biochemical and immunological evidence for the detection of a uteroglobin-like protein in the wet epithelial living of the respiratory tract of human neonates. Because inhibition of phospholipase A2 may modulate tissue eicosanoid levels and since many eicosanoids (i.e. prostaglandins and leukotrienes etc.) are well known regulators of smooth muscle contractility, cellular migration and inflammatory processes, the discovery of this protein in the human respiratory tract may have important physiological implications.",
author = "Ramasubbareddy Dhanireddy and Tadahiro Kikukawa and Mukherjee, {Anil B.}",
year = "1988",
month = "5",
day = "16",
doi = "10.1016/S0006-291X(88)80448-0",
language = "English (US)",
volume = "152",
pages = "1447--1454",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Detection of a rabbit uteroglobin-like protein in human neonatal tracheobronchial washings

AU - Dhanireddy, Ramasubbareddy

AU - Kikukawa, Tadahiro

AU - Mukherjee, Anil B.

PY - 1988/5/16

Y1 - 1988/5/16

N2 - Uteroglobin is a steroid hormone dependent, low molecular weight, secretory protein with many immunomodulatory properties. Immunomodulation by this protein may, at least in part, be related to its inhibitory effects on phospholipase A2 activity. Although uteroglobin is conclusively found in the rabbit, its presence in the human is controversial. Here, we present biochemical and immunological evidence for the detection of a uteroglobin-like protein in the wet epithelial living of the respiratory tract of human neonates. Because inhibition of phospholipase A2 may modulate tissue eicosanoid levels and since many eicosanoids (i.e. prostaglandins and leukotrienes etc.) are well known regulators of smooth muscle contractility, cellular migration and inflammatory processes, the discovery of this protein in the human respiratory tract may have important physiological implications.

AB - Uteroglobin is a steroid hormone dependent, low molecular weight, secretory protein with many immunomodulatory properties. Immunomodulation by this protein may, at least in part, be related to its inhibitory effects on phospholipase A2 activity. Although uteroglobin is conclusively found in the rabbit, its presence in the human is controversial. Here, we present biochemical and immunological evidence for the detection of a uteroglobin-like protein in the wet epithelial living of the respiratory tract of human neonates. Because inhibition of phospholipase A2 may modulate tissue eicosanoid levels and since many eicosanoids (i.e. prostaglandins and leukotrienes etc.) are well known regulators of smooth muscle contractility, cellular migration and inflammatory processes, the discovery of this protein in the human respiratory tract may have important physiological implications.

UR - http://www.scopus.com/inward/record.url?scp=0023889141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023889141&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(88)80448-0

DO - 10.1016/S0006-291X(88)80448-0

M3 - Article

VL - 152

SP - 1447

EP - 1454

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -