Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry

Lawrence M. Jordan, Frank A. DiBianca, Jeno I.M.D. Sebes, Donald Thomason, Herbert D. Zeman, Peter G. Davis, Dona Kambeyanda, Gao Li, Gunnar Lovhoiden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A method utilizing digital dual-energy subtraction X-ray radiography for measuring calcium densities localized to the cortical and cancellous regions of bone cross sections is described. The method is being used to study calcium loss in femurs of two differently treated groups of rats. In each experimental cohort, one group of rats is restrained from weightbearing on hind limbs by suspension from a tail harness. The other (control) group is allowed normal weightbearing on all limbs. The densitometry data for each rat leg consists of six X-ray projection images acquired at roughly equal angles about the bone axis by an intensifying screen/CCD camera imaging system. Images of bone cross sections are reconstructed by application of a maximum entropy algorithm constrained by the six projection images. The observed density data are further discriminated into cortical, cancellous and external regions on the basis of reference levels found on image density histograms.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsLeonard J. Cerullo, Kenneth S. Heiferman, Hong Liu, Halina Podbielska, Abund O. Wist
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages234-241
Number of pages8
ISBN (Print)0819414271
StatePublished - Dec 1 1994
EventClinical Applications of Modern Imaging Technology II - Los Angeles, CA, USA
Duration: Jan 23 1994Jan 23 1994

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2132
ISSN (Print)0277-786X

Other

OtherClinical Applications of Modern Imaging Technology II
CityLos Angeles, CA, USA
Period1/23/941/23/94

Fingerprint

bones
rats
Rats
Bone
X rays
Calcium
limbs
X ray radiography
calcium
x rays
projection
CCD cameras
harnesses
femur
Imaging systems
cross sections
radiography
Entropy
histograms
subtraction

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Jordan, L. M., DiBianca, F. A., Sebes, J. I. M. D., Thomason, D., Zeman, H. D., Davis, P. G., ... Lovhoiden, G. (1994). Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry. In L. J. Cerullo, K. S. Heiferman, H. Liu, H. Podbielska, & A. O. Wist (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 234-241). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2132). Publ by Society of Photo-Optical Instrumentation Engineers.

Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry. / Jordan, Lawrence M.; DiBianca, Frank A.; Sebes, Jeno I.M.D.; Thomason, Donald; Zeman, Herbert D.; Davis, Peter G.; Kambeyanda, Dona; Li, Gao; Lovhoiden, Gunnar.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Leonard J. Cerullo; Kenneth S. Heiferman; Hong Liu; Halina Podbielska; Abund O. Wist. Publ by Society of Photo-Optical Instrumentation Engineers, 1994. p. 234-241 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2132).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jordan, LM, DiBianca, FA, Sebes, JIMD, Thomason, D, Zeman, HD, Davis, PG, Kambeyanda, D, Li, G & Lovhoiden, G 1994, Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry. in LJ Cerullo, KS Heiferman, H Liu, H Podbielska & AO Wist (eds), Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 2132, Publ by Society of Photo-Optical Instrumentation Engineers, pp. 234-241, Clinical Applications of Modern Imaging Technology II, Los Angeles, CA, USA, 1/23/94.
Jordan LM, DiBianca FA, Sebes JIMD, Thomason D, Zeman HD, Davis PG et al. Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry. In Cerullo LJ, Heiferman KS, Liu H, Podbielska H, Wist AO, editors, Proceedings of SPIE - The International Society for Optical Engineering. Publ by Society of Photo-Optical Instrumentation Engineers. 1994. p. 234-241. (Proceedings of SPIE - The International Society for Optical Engineering).
Jordan, Lawrence M. ; DiBianca, Frank A. ; Sebes, Jeno I.M.D. ; Thomason, Donald ; Zeman, Herbert D. ; Davis, Peter G. ; Kambeyanda, Dona ; Li, Gao ; Lovhoiden, Gunnar. / Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry. Proceedings of SPIE - The International Society for Optical Engineering. editor / Leonard J. Cerullo ; Kenneth S. Heiferman ; Hong Liu ; Halina Podbielska ; Abund O. Wist. Publ by Society of Photo-Optical Instrumentation Engineers, 1994. pp. 234-241 (Proceedings of SPIE - The International Society for Optical Engineering).
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