Determinants of stroke volume in the isolated canine heart

Karl Weber, J. S. Janicki, R. C. Reeves, L. L. Hefner, T. J. Reeves

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To assess the influence of end diastolic volume (EDV) and pressure (EDP), the pressure resisting shortening (Ps), and inotropic state on left ventricular stroke volume (SV), a pressure servo system was utilized in 14 paced, isolated canine hearts. Ventricular volume (intraventricular balloon) and pressure were monitored and controlled with the servo system. For a given perfusate calcium concentration (Ca 2+) and constant EDV or EDP, a series of increasing Ps were imposed to isovolumic contraction (P 0). An inverse, almost linear, relation was found between SV and Ps (r = 0.97) for any constant EDP, heart rate, and Ca 2+ and each line was characterized by its slope and P 0. When EDV was held constant and Ps increased, EDP declined, indicating an increase in apparent ventricular compliance and the SV Ps relation became curvilinear. In any heart the SV Ps slope became less negative as EDP was increased during excess Ca 2+ (P < 0.01). Stroke work for any EDP or inotropic state was found to peak at 63% (52-76%) of P 0. It is concluded that for any initial ventricular fiber length, the amount of shortening or SV is dependant on Ps and inotropic state; the SV Ps relation is linear for a constant EDP. Such information may not only serve to predict SV but may also provide the basis for therapeutic manipulations which aid the diseased heart.

Original languageEnglish (US)
Pages (from-to)742-747
Number of pages6
JournalJournal of applied physiology
Volume37
Issue number5
StatePublished - Dec 1 1974

Fingerprint

Stroke Volume
Canidae
Pressure
Cardiac Volume
Ventricular Pressure
Compliance
Heart Diseases
Heart Rate
Stroke

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Weber, K., Janicki, J. S., Reeves, R. C., Hefner, L. L., & Reeves, T. J. (1974). Determinants of stroke volume in the isolated canine heart. Journal of applied physiology, 37(5), 742-747.

Determinants of stroke volume in the isolated canine heart. / Weber, Karl; Janicki, J. S.; Reeves, R. C.; Hefner, L. L.; Reeves, T. J.

In: Journal of applied physiology, Vol. 37, No. 5, 01.12.1974, p. 742-747.

Research output: Contribution to journalArticle

Weber, K, Janicki, JS, Reeves, RC, Hefner, LL & Reeves, TJ 1974, 'Determinants of stroke volume in the isolated canine heart', Journal of applied physiology, vol. 37, no. 5, pp. 742-747.
Weber K, Janicki JS, Reeves RC, Hefner LL, Reeves TJ. Determinants of stroke volume in the isolated canine heart. Journal of applied physiology. 1974 Dec 1;37(5):742-747.
Weber, Karl ; Janicki, J. S. ; Reeves, R. C. ; Hefner, L. L. ; Reeves, T. J. / Determinants of stroke volume in the isolated canine heart. In: Journal of applied physiology. 1974 ; Vol. 37, No. 5. pp. 742-747.
@article{9a153f45d54f43b09dbdfbb68aa075df,
title = "Determinants of stroke volume in the isolated canine heart",
abstract = "To assess the influence of end diastolic volume (EDV) and pressure (EDP), the pressure resisting shortening (Ps), and inotropic state on left ventricular stroke volume (SV), a pressure servo system was utilized in 14 paced, isolated canine hearts. Ventricular volume (intraventricular balloon) and pressure were monitored and controlled with the servo system. For a given perfusate calcium concentration (Ca 2+) and constant EDV or EDP, a series of increasing Ps were imposed to isovolumic contraction (P 0). An inverse, almost linear, relation was found between SV and Ps (r = 0.97) for any constant EDP, heart rate, and Ca 2+ and each line was characterized by its slope and P 0. When EDV was held constant and Ps increased, EDP declined, indicating an increase in apparent ventricular compliance and the SV Ps relation became curvilinear. In any heart the SV Ps slope became less negative as EDP was increased during excess Ca 2+ (P < 0.01). Stroke work for any EDP or inotropic state was found to peak at 63{\%} (52-76{\%}) of P 0. It is concluded that for any initial ventricular fiber length, the amount of shortening or SV is dependant on Ps and inotropic state; the SV Ps relation is linear for a constant EDP. Such information may not only serve to predict SV but may also provide the basis for therapeutic manipulations which aid the diseased heart.",
author = "Karl Weber and Janicki, {J. S.} and Reeves, {R. C.} and Hefner, {L. L.} and Reeves, {T. J.}",
year = "1974",
month = "12",
day = "1",
language = "English (US)",
volume = "37",
pages = "742--747",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Determinants of stroke volume in the isolated canine heart

AU - Weber, Karl

AU - Janicki, J. S.

AU - Reeves, R. C.

AU - Hefner, L. L.

AU - Reeves, T. J.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - To assess the influence of end diastolic volume (EDV) and pressure (EDP), the pressure resisting shortening (Ps), and inotropic state on left ventricular stroke volume (SV), a pressure servo system was utilized in 14 paced, isolated canine hearts. Ventricular volume (intraventricular balloon) and pressure were monitored and controlled with the servo system. For a given perfusate calcium concentration (Ca 2+) and constant EDV or EDP, a series of increasing Ps were imposed to isovolumic contraction (P 0). An inverse, almost linear, relation was found between SV and Ps (r = 0.97) for any constant EDP, heart rate, and Ca 2+ and each line was characterized by its slope and P 0. When EDV was held constant and Ps increased, EDP declined, indicating an increase in apparent ventricular compliance and the SV Ps relation became curvilinear. In any heart the SV Ps slope became less negative as EDP was increased during excess Ca 2+ (P < 0.01). Stroke work for any EDP or inotropic state was found to peak at 63% (52-76%) of P 0. It is concluded that for any initial ventricular fiber length, the amount of shortening or SV is dependant on Ps and inotropic state; the SV Ps relation is linear for a constant EDP. Such information may not only serve to predict SV but may also provide the basis for therapeutic manipulations which aid the diseased heart.

AB - To assess the influence of end diastolic volume (EDV) and pressure (EDP), the pressure resisting shortening (Ps), and inotropic state on left ventricular stroke volume (SV), a pressure servo system was utilized in 14 paced, isolated canine hearts. Ventricular volume (intraventricular balloon) and pressure were monitored and controlled with the servo system. For a given perfusate calcium concentration (Ca 2+) and constant EDV or EDP, a series of increasing Ps were imposed to isovolumic contraction (P 0). An inverse, almost linear, relation was found between SV and Ps (r = 0.97) for any constant EDP, heart rate, and Ca 2+ and each line was characterized by its slope and P 0. When EDV was held constant and Ps increased, EDP declined, indicating an increase in apparent ventricular compliance and the SV Ps relation became curvilinear. In any heart the SV Ps slope became less negative as EDP was increased during excess Ca 2+ (P < 0.01). Stroke work for any EDP or inotropic state was found to peak at 63% (52-76%) of P 0. It is concluded that for any initial ventricular fiber length, the amount of shortening or SV is dependant on Ps and inotropic state; the SV Ps relation is linear for a constant EDP. Such information may not only serve to predict SV but may also provide the basis for therapeutic manipulations which aid the diseased heart.

UR - http://www.scopus.com/inward/record.url?scp=0016172660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016172660&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 742

EP - 747

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -